204239

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1435875..1436712 Replicon chromosome
Accession NZ_CP075697
Organism Escherichia coli strain STEC2018-607

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag JFX52_RS07165 Protein ID WP_000227784.1
Coordinates 1436170..1436712 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag JFX52_RS07160 Protein ID WP_001297137.1
Coordinates 1435875..1436186 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX52_RS07135 (1430895) 1430895..1431842 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
JFX52_RS07140 (1431864) 1431864..1433855 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
JFX52_RS07145 (1433845) 1433845..1434459 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
JFX52_RS07150 (1434459) 1434459..1434788 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
JFX52_RS07155 (1434800) 1434800..1435690 + 891 WP_000971336.1 heme o synthase -
JFX52_RS07160 (1435875) 1435875..1436186 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
JFX52_RS07165 (1436170) 1436170..1436712 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
JFX52_RS07170 (1436768) 1436768..1437703 - 936 WP_001368479.1 tetratricopeptide repeat protein -
JFX52_RS07175 (1438111) 1438111..1439475 + 1365 WP_001000974.1 MFS transporter -
JFX52_RS07180 (1439603) 1439603..1440094 - 492 WP_001138904.1 nucleotide binding protein YajQ -
JFX52_RS07185 (1440262) 1440262..1441173 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T204239 WP_000227784.1 NZ_CP075697:1436170-1436712 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T204239 NZ_CP100679:42970-43122 [Salmonella enterica subsp. enterica serovar Anatum]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT204239 WP_001297137.1 NZ_CP075697:1435875-1436186 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT204239 NZ_CP100679:c42918-42858 [Salmonella enterica subsp. enterica serovar Anatum]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References