Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3471573..3472267 Replicon chromosome
Accession NZ_CP075691
Organism Streptomyces sp. 135

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KKZ08_RS15530 Protein ID WP_223775013.1
Coordinates 3471866..3472267 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KKZ08_RS15525 Protein ID WP_223775012.1
Coordinates 3471573..3471869 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ08_RS15500 3467399..3468157 - 759 WP_223775007.1 LPXTG cell wall anchor domain-containing protein -
KKZ08_RS15505 3468371..3468880 - 510 WP_223775008.1 ATP-binding protein -
KKZ08_RS15510 3469131..3469499 - 369 WP_223775009.1 STAS domain-containing protein -
KKZ08_RS15515 3469750..3470691 + 942 WP_223775010.1 RNA polymerase sigma factor SigF -
KKZ08_RS15520 3470770..3471468 - 699 WP_223775011.1 aspartate/glutamate racemase family protein -
KKZ08_RS15525 3471573..3471869 + 297 WP_223775012.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KKZ08_RS15530 3471866..3472267 + 402 WP_223775013.1 type II toxin-antitoxin system VapC family toxin Toxin
KKZ08_RS15535 3472264..3472671 - 408 WP_223775014.1 ATP-binding protein -
KKZ08_RS15540 3472788..3473639 + 852 WP_223775015.1 helix-turn-helix transcriptional regulator -
KKZ08_RS15545 3473620..3473835 + 216 WP_223775016.1 DUF397 domain-containing protein -
KKZ08_RS15550 3473870..3475045 - 1176 WP_223779068.1 MFS transporter -
KKZ08_RS15555 3475169..3475774 + 606 WP_223775017.1 TetR/AcrR family transcriptional regulator -
KKZ08_RS15560 3475801..3476973 - 1173 WP_223775018.1 imidazolonepropionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-43)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14303.46 Da        Isoelectric Point: 6.0857

>T204234 WP_223775013.1 NZ_CP075691:3471866-3472267 [Streptomyces sp. 135]
VIYLDSCALLKLVLREAETDALRTFLAARAAEGHVTSALSQTEVFRTLVRAGADPEVGDAAEALLDRLLRIRVTDPVLRA
AGMFPARHLRSLDAIHLASAEYLEHALTAFVTYDKRLAAAALDRGLPVEAPGA

Download         Length: 402 bp

>T204234 NZ_CP100678:c4011792-4011505 [Salmonella enterica subsp. enterica serovar Anatum]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCAGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10820.20 Da        Isoelectric Point: 4.9001

>AT204234 WP_223775012.1 NZ_CP075691:3471573-3471869 [Streptomyces sp. 135]
MTTRVPIRQLQQHASELIDRVAAGERVEITRNGRLIAVLGPPDPEQRVMEDLVRTGTVDPDNAASARGLGDWEPLAAHPG
ASSKLSEVLLRMREEEDR

Download         Length: 297 bp

>AT204234 NZ_CP100678:c4011518-4011216 [Salmonella enterica subsp. enterica serovar Anatum]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References