Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 5700024..5700663 Replicon chromosome
Accession NZ_CP075686
Organism Pseudomonas amygdali pv. lachrymans strain 8

Toxin (Protein)


Gene name hicA Uniprot ID A0A3M5IA75
Locus tag C4C37_RS26070 Protein ID WP_005745047.1
Coordinates 5700024..5700206 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Q0DRU8
Locus tag C4C37_RS26075 Protein ID WP_016981256.1
Coordinates 5700238..5700663 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4C37_RS26035 (C4C37_26035) 5695385..5695978 + 594 WP_002551454.1 imidazoleglycerol-phosphate dehydratase HisB -
C4C37_RS26040 (C4C37_26040) 5695978..5696616 + 639 WP_005745046.1 imidazole glycerol phosphate synthase subunit HisH -
C4C37_RS26045 (C4C37_26045) 5696621..5696881 + 261 WP_002551456.1 DUF2164 domain-containing protein -
C4C37_RS26050 (C4C37_26050) 5696989..5697726 + 738 WP_002551457.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
C4C37_RS26055 (C4C37_26055) 5697746..5698516 + 771 WP_002551458.1 imidazole glycerol phosphate synthase subunit HisF -
C4C37_RS26060 (C4C37_26060) 5698702..5699457 + 756 WP_004663214.1 ABC transporter substrate-binding protein -
C4C37_RS26065 (C4C37_26065) 5699462..5699702 - 241 Protein_5166 serine protease -
C4C37_RS26070 (C4C37_26070) 5700024..5700206 + 183 WP_005745047.1 type II toxin-antitoxin system HicA family toxin Toxin
C4C37_RS26075 (C4C37_26075) 5700238..5700663 + 426 WP_016981256.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4C37_RS26080 (C4C37_26080) 5700718..5701500 - 783 WP_005745049.1 divergent polysaccharide deacetylase family protein -
C4C37_RS26085 (C4C37_26085) 5701504..5702847 - 1344 WP_005745050.1 S41 family peptidase -
C4C37_RS26090 (C4C37_26090) 5702881..5704203 - 1323 WP_029240926.1 murein hydrolase activator EnvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6892.00 Da        Isoelectric Point: 10.6211

>T204230 WP_005745047.1 NZ_CP075686:5700024-5700206 [Pseudomonas amygdali pv. lachrymans]
MKCNEFRRWLQAQGAEFRAAKGSHFKIYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T204230 NZ_CP100678:1949571-1949674 [Salmonella enterica subsp. enterica serovar Anatum]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15783.24 Da        Isoelectric Point: 5.2548

>AT204230 WP_016981256.1 NZ_CP075686:5700238-5700663 [Pseudomonas amygdali pv. lachrymans]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA

Download         Length: 426 bp

>AT204230 NZ_CP100678:c1949676-1949531 [Salmonella enterica subsp. enterica serovar Anatum]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M5IA75

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0DRU8

References