Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 5289023..5289618 Replicon chromosome
Accession NZ_CP075686
Organism Pseudomonas amygdali pv. lachrymans strain 8

Toxin (Protein)


Gene name relE Uniprot ID A0A3M3ZKH5
Locus tag C4C37_RS24080 Protein ID WP_005746690.1
Coordinates 5289023..5289325 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0P9S822
Locus tag C4C37_RS24085 Protein ID WP_005746689.1
Coordinates 5289328..5289618 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4C37_RS24060 (C4C37_24060) 5284356..5285633 - 1278 WP_005746696.1 precorrin-3B synthase -
C4C37_RS24065 (C4C37_24065) 5285822..5287024 + 1203 WP_005746695.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
C4C37_RS24070 (C4C37_24070) 5287024..5288136 + 1113 WP_005746694.1 cobalt-precorrin-5B (C(1))-methyltransferase -
C4C37_RS24075 (C4C37_24075) 5288133..5288873 + 741 WP_005746691.1 cobalt-precorrin-6A reductase -
C4C37_RS24080 (C4C37_24080) 5289023..5289325 + 303 WP_005746690.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4C37_RS24085 (C4C37_24085) 5289328..5289618 + 291 WP_005746689.1 putative addiction module antidote protein Antitoxin
C4C37_RS24090 (C4C37_24090) 5289689..5290150 + 462 WP_005746687.1 copper chaperone PCu(A)C -
C4C37_RS24095 (C4C37_24095) 5290164..5290598 + 435 WP_005746686.1 DUF2946 domain-containing protein -
C4C37_RS24100 (C4C37_24100) 5290683..5292056 + 1374 WP_005746685.1 PepSY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-86)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11477.21 Da        Isoelectric Point: 10.6008

>T204229 WP_005746690.1 NZ_CP075686:5289023-5289325 [Pseudomonas amygdali pv. lachrymans]
MNRFEQTPAFAEWLRSLKDSIGRARILARIRAAELGNFGDCDALGQGVRELRIHHGPGYRVYFARRTGVVYLLLIAGDKS
SQKRDIKFARQLARELCERE

Download         Length: 303 bp

>T204229 NZ_CP100678:1829787-1830119 [Salmonella enterica subsp. enterica serovar Anatum]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGTCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCCGTTGTTATTCCCGTCACCAGCGGTGGAAACTTCGCCCGCG
CAGCCGGTTTTACCGTCTCACTGGAGGGGGCGGGAACCAAAACAACGGGCGTGATCCGCTGCGACCAGCCCAGAACTATT
GATATGGGCGCCCGAAATGGTAAGCGACTGGAGCGCATACCCGACGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10500.87 Da        Isoelectric Point: 4.5720

>AT204229 WP_005746689.1 NZ_CP075686:5289328-5289618 [Pseudomonas amygdali pv. lachrymans]
MNNETTPFDTVDYLKTPEDMANYLDACLEEDSGDGLLVRAALNDIARAYGMTQIARDTGLGRESLYKALGANGNPEFTTI
MKVVRAMGIKLHASTR

Download         Length: 291 bp

>AT204229 NZ_CP100678:1829529-1829786 [Salmonella enterica subsp. enterica serovar Anatum]
ATGTATACCACTCGTCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGCTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGAGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3ZKH5

Antitoxin

Source ID Structure
AlphaFold DB A0A0P9S822

References