Detailed information of TA system TA204228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 4386024..4386537
• Replicon: chromosome
• Accession: NZ_CP075686
• Organism: Pseudomonas amygdali pv. lachrymans strain 8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4C37_RS19995
• Protein ID: WP_004658391.1
• Coordinates: 4386253..4386537 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0N8T2X1
• Locus tag: C4C37_RS19990
• Protein ID: WP_029241049.1
• Coordinates: 4386024..4386263 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4C37_RS19970 (C4C37_19970)	4382133..4382918	+	786	WP_002552796.1	outer membrane protein OmpK	-
C4C37_RS19975 (C4C37_19975)	4383097..4384005	-	909	WP_005744311.1	DUF808 domain-containing protein	-
C4C37_RS19980 (C4C37_19980)	4384155..4384661	-	507	WP_004658394.1	Lrp/AsnC family transcriptional regulator	-
C4C37_RS19985 (C4C37_19985)	4384848..4385864	+	1017	WP_002552793.1	1-aminocyclopropane-1-carboxylate deaminase	-
C4C37_RS19990 (C4C37_19990)	4386024..4386263	+	240	WP_029241049.1	CopG family ribbon-helix-helix protein	Antitoxin
C4C37_RS19995 (C4C37_19995)	4386253..4386537	+	285	WP_004658391.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4C37_RS20000 (C4C37_20000)	4386574..4387428	-	855	WP_004658390.1	LysR family transcriptional regulator	-
C4C37_RS20005 (C4C37_20005)	4387503..4388435	+	933	WP_039847441.1	DMT family transporter	-
C4C37_RS20010 (C4C37_20010)	4388466..4390394	-	1929	WP_010198401.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10647.31 Da
• Isoelectric Point: 10.4249

>T204228 WP_004658391.1 NZ_CP075686:4386253-4386537 [Pseudomonas amygdali pv. lachrymans]
MQVEWLKTALKNLDEEAAYIAQDNPAAAAAFVKAIQSSVTQLASFPAMGREGRIAGTREWPLPDLPYLIPYRIRSGRLQV
LRIFHTRRQSPPVW

Nucleotide

• Length: 285 bp

>T204228 NZ_CP100678:c980327-979800 [Salmonella enterica subsp. enterica serovar Anatum]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTGGCTTGCTCTTGATAATTCTG
ACGTTACGCTTATTCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGACGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTTTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTGAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8715.80 Da
• Isoelectric Point: 4.4354

>AT204228 WP_029241049.1 NZ_CP075686:4386024-4386263 [Pseudomonas amygdali pv. lachrymans]
MSTMSLRLPDEMADTLAHLAKATGRSKSFLALDALREYLTREAWQIAEIQRAIEEADAGEFANTEDVKAVMDKWSGNAG

Nucleotide

• Length: 240 bp

>AT204228 NZ_CP100678:c980614-980324 [Salmonella enterica subsp. enterica serovar Anatum]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0N8T2X1