Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1241207..1242124 | Replicon | chromosome |
| Accession | NZ_CP075681 | ||
| Organism | Bacillus velezensis strain C5 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | I2HQ15 |
| Locus tag | KK132_RS06495 | Protein ID | WP_007407256.1 |
| Coordinates | 1241378..1242124 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | I2HQ14 |
| Locus tag | KK132_RS06490 | Protein ID | WP_003154807.1 |
| Coordinates | 1241207..1241377 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KK132_RS06450 (KK132_06395) | 1236440..1238062 | + | 1623 | WP_032874601.1 | pyocin knob domain-containing protein | - |
| KK132_RS06455 (KK132_06400) | 1238075..1238446 | + | 372 | WP_032874603.1 | XkdW family protein | - |
| KK132_RS06460 (KK132_06405) | 1238451..1238648 | + | 198 | WP_032874605.1 | XkdX family protein | - |
| KK132_RS06465 (KK132_06410) | 1238705..1239466 | + | 762 | WP_032874607.1 | hypothetical protein | - |
| KK132_RS06470 (KK132_06415) | 1239518..1239781 | + | 264 | WP_003154815.1 | hemolysin XhlA family protein | - |
| KK132_RS06475 (KK132_06420) | 1239795..1240058 | + | 264 | WP_003154813.1 | phage holin | - |
| KK132_RS06480 (KK132_06425) | 1240072..1240950 | + | 879 | WP_032874609.1 | N-acetylmuramoyl-L-alanine amidase | - |
| KK132_RS06485 | 1240985..1241110 | - | 126 | WP_003154809.1 | hypothetical protein | - |
| KK132_RS06490 (KK132_06430) | 1241207..1241377 | - | 171 | WP_003154807.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| KK132_RS06495 (KK132_06435) | 1241378..1242124 | - | 747 | WP_007407256.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| KK132_RS06500 (KK132_06440) | 1242229..1243227 | - | 999 | WP_032874611.1 | inorganic phosphate transporter | - |
| KK132_RS06505 (KK132_06445) | 1243240..1243857 | - | 618 | WP_032874614.1 | DUF47 domain-containing protein | - |
| KK132_RS06510 (KK132_06450) | 1244143..1245459 | - | 1317 | WP_032874616.1 | amino acid permease | - |
| KK132_RS06515 (KK132_06455) | 1245781..1246731 | + | 951 | WP_032874618.1 | ring-cleaving dioxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1209102..1299976 | 90874 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29077.57 Da Isoelectric Point: 4.7755
>T204218 WP_007407256.1 NZ_CP075681:c1242124-1241378 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
Download Length: 747 bp
>T204218 NZ_CP100670:c4180324-4180049 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGGACAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGACAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6676.74 Da Isoelectric Point: 10.9273
>AT204218 WP_003154807.1 NZ_CP075681:c1241377-1241207 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
Download Length: 171 bp
>AT204218 NZ_CP100670:c4180587-4180327 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCATTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCATTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|