Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4182642..4183440 Replicon chromosome
Accession NZ_CP075665
Organism Escherichia coli strain STEC2018-553

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0P7PH46
Locus tag JFY30_RS20680 Protein ID WP_000854896.1
Coordinates 4182642..4183019 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A234XUW5
Locus tag JFY30_RS20685 Protein ID WP_024175300.1
Coordinates 4183066..4183440 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY30_RS20650 (4177919) 4177919..4179457 - 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -
JFY30_RS29095 (4179717) 4179717..4179876 - 160 Protein_4068 integrase -
JFY30_RS20655 (4180339) 4180339..4180665 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JFY30_RS20660 (4180662) 4180662..4180925 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
JFY30_RS20665 (4180997) 4180997..4181863 - 867 WP_000014511.1 DUF4942 domain-containing protein -
JFY30_RS20670 (4181948) 4181948..4182145 - 198 WP_000839256.1 DUF957 domain-containing protein -
JFY30_RS20675 (4182157) 4182157..4182645 - 489 WP_000761662.1 DUF5983 family protein -
JFY30_RS20680 (4182642) 4182642..4183019 - 378 WP_000854896.1 TA system toxin CbtA family protein Toxin
JFY30_RS20685 (4183066) 4183066..4183440 - 375 WP_024175300.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JFY30_RS20690 (4183603) 4183603..4183824 - 222 WP_000692358.1 DUF987 domain-containing protein -
JFY30_RS20695 (4183887) 4183887..4184363 - 477 WP_001186727.1 RadC family protein -
JFY30_RS20700 (4184379) 4184379..4184864 - 486 WP_000214386.1 antirestriction protein -
JFY30_RS20705 (4184954) 4184954..4185772 - 819 WP_001234751.1 DUF932 domain-containing protein -
JFY30_RS20710 (4185863) 4185863..4186096 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4170430..4246434 76004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14210.19 Da        Isoelectric Point: 7.2920

>T204201 WP_000854896.1 NZ_CP075665:c4183019-4182642 [Escherichia coli]
MKTLSDTHVREASRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T204201 NZ_CP100666:c4353418-4352933 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13664.42 Da        Isoelectric Point: 6.4757

>AT204201 WP_024175300.1 NZ_CP075665:c4183440-4183066 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVKPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHSVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS

Download         Length: 375 bp

>AT204201 NZ_CP100666:c4353693-4353406 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7PH46

Antitoxin

Source ID Structure
AlphaFold DB A0A234XUW5

References