Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3647540..3648341 Replicon chromosome
Accession NZ_CP075665
Organism Escherichia coli strain STEC2018-553

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H0JYG3
Locus tag JFY30_RS18220 Protein ID WP_001094432.1
Coordinates 3647964..3648341 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7NA60
Locus tag JFY30_RS18215 Protein ID WP_001380152.1
Coordinates 3647540..3647917 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY30_RS18180 (3644193) 3644193..3644654 + 462 WP_000581501.1 IrmA family protein -
JFY30_RS18185 (3644722) 3644722..3644955 + 234 WP_096849319.1 DUF905 family protein -
JFY30_RS18190 (3645055) 3645055..3645876 + 822 WP_001241714.1 DUF932 domain-containing protein -
JFY30_RS18195 (3645876) 3645876..3646076 + 201 WP_001367430.1 hypothetical protein -
JFY30_RS18200 (3646210) 3646210..3646683 + 474 WP_000855069.1 antirestriction protein -
JFY30_RS18205 (3646698) 3646698..3647174 + 477 WP_001186704.1 RadC family protein -
JFY30_RS18210 (3647243) 3647243..3647464 + 222 WP_000692313.1 DUF987 domain-containing protein -
JFY30_RS18215 (3647540) 3647540..3647917 + 378 WP_001380152.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JFY30_RS18220 (3647964) 3647964..3648341 + 378 WP_001094432.1 TA system toxin CbtA family protein Toxin
JFY30_RS18225 (3648338) 3648338..3648826 + 489 WP_032308658.1 DUF5983 family protein -
JFY30_RS18230 (3648838) 3648838..3649035 + 198 WP_000839249.1 DUF957 domain-containing protein -
JFY30_RS18235 (3649120) 3649120..3649965 + 846 WP_001280530.1 DUF4942 domain-containing protein -
JFY30_RS28825 (3650199) 3650199..3650360 + 162 Protein_3605 RhuM family protein -
JFY30_RS18240 (3650757) 3650757..3651941 + 1185 WP_001172876.1 sugar efflux transporter -
JFY30_RS18245 (3652052) 3652052..3652975 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14136.99 Da        Isoelectric Point: 6.4729

>T204198 WP_001094432.1 NZ_CP075665:3647964-3648341 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T204198 NZ_CP100666:3834766-3836091 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13679.52 Da        Isoelectric Point: 5.8682

>AT204198 WP_001380152.1 NZ_CP075665:3647540-3647917 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT204198 NZ_CP100666:3834468-3834761 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0JYG3

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7NA60

References