Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 1642521..1643110 | Replicon | chromosome |
| Accession | NZ_CP075665 | ||
| Organism | Escherichia coli strain STEC2018-553 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A398TMA1 |
| Locus tag | JFY30_RS08280 | Protein ID | WP_000513533.1 |
| Coordinates | 1642862..1643110 (-) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A3J8R0E8 |
| Locus tag | JFY30_RS08275 | Protein ID | WP_000681611.1 |
| Coordinates | 1642521..1642865 (-) | Length | 115 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFY30_RS08240 (1638972) | 1638972..1639349 | - | 378 | WP_001271433.1 | hypothetical protein | - |
| JFY30_RS28685 (1639557) | 1639557..1639826 | - | 270 | WP_001115081.1 | hypothetical protein | - |
| JFY30_RS08250 (1639881) | 1639881..1640084 | - | 204 | WP_001240876.1 | Cro/CI family transcriptional regulator | - |
| JFY30_RS08255 (1640180) | 1640180..1640893 | + | 714 | WP_001056249.1 | LexA family transcriptional regulator | - |
| JFY30_RS08260 (1640990) | 1640990..1641151 | + | 162 | WP_071525586.1 | transmembrane anchored protein | - |
| JFY30_RS08265 (1641331) | 1641331..1642233 | + | 903 | WP_000081325.1 | serine dehydrogenasease | - |
| JFY30_RS08270 (1642234) | 1642234..1642404 | + | 171 | WP_167580584.1 | hypothetical protein | - |
| JFY30_RS08275 (1642521) | 1642521..1642865 | - | 345 | WP_000681611.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| JFY30_RS08280 (1642862) | 1642862..1643110 | - | 249 | WP_000513533.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| JFY30_RS08285 (1643874) | 1643874..1644644 | + | 771 | WP_000529245.1 | Rha family transcriptional regulator | - |
| JFY30_RS08290 (1644715) | 1644715..1644927 | + | 213 | WP_000917251.1 | hypothetical protein | - |
| JFY30_RS08295 (1644939) | 1644939..1645220 | + | 282 | WP_000934192.1 | hypothetical protein | - |
| JFY30_RS08300 (1645241) | 1645241..1645522 | + | 282 | WP_000995348.1 | host nuclease inhibitor GamL | - |
| JFY30_RS08305 (1645540) | 1645540..1646490 | + | 951 | WP_000459722.1 | RecT family recombinase | - |
| JFY30_RS08310 (1646487) | 1646487..1647176 | + | 690 | WP_000187063.1 | YqaJ viral recombinase family protein | - |
| JFY30_RS08315 (1647176) | 1647176..1647763 | + | 588 | WP_033805714.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | stxB / stxA | 1590134..1661093 | 70959 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9436.07 Da Isoelectric Point: 10.3195
>T204192 WP_000513533.1 NZ_CP075665:c1643110-1642862 [Escherichia coli]
MGKADKLLEKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
MGKADKLLEKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
Download Length: 249 bp
>T204192 NZ_CP100666:c1076891-1076673 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 115 a.a. Molecular weight: 13065.80 Da Isoelectric Point: 4.6791
>AT204192 WP_000681611.1 NZ_CP075665:c1642865-1642521 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEASTLAELEQEFKTSVELYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVNHHTGA
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEASTLAELEQEFKTSVELYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVNHHTGA
Download Length: 345 bp
>AT204192 NZ_CP100666:c1077293-1076919 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A398TMA1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3J8R0E8 |