Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1197287..1198122 Replicon chromosome
Accession NZ_CP075663
Organism Escherichia coli strain STEC2017-197

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JFX55_RS06180 Protein ID WP_062871540.1
Coordinates 1197287..1197664 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E1LVG0
Locus tag JFX55_RS06185 Protein ID WP_001285484.1
Coordinates 1197754..1198122 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX55_RS06140 (1192295) 1192295..1192786 - 492 WP_001297187.1 DUF1097 domain-containing protein -
JFX55_RS06145 (1192888) 1192888..1193442 - 555 WP_001001902.1 molecular chaperone YcdY -
JFX55_RS06150 (1193466) 1193466..1194203 - 738 WP_000283664.1 zinc-binding phosphatase -
JFX55_RS06155 (1194258) 1194258..1195195 - 938 Protein_1212 glyoxylate/hydroxypyruvate reductase GhrA -
JFX55_RS06165 (1195666) 1195666..1196508 - 843 WP_001280423.1 DUF4942 domain-containing protein -
JFX55_RS06170 (1196593) 1196593..1196790 - 198 WP_000839242.1 DUF957 domain-containing protein -
JFX55_RS06175 (1196802) 1196802..1197290 - 489 WP_198790226.1 DUF5983 family protein -
JFX55_RS06180 (1197287) 1197287..1197664 - 378 WP_062871540.1 TA system toxin CbtA family protein Toxin
JFX55_RS06185 (1197754) 1197754..1198122 - 369 WP_001285484.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JFX55_RS06190 (1198172) 1198172..1198816 - 645 WP_198790225.1 antitoxin of toxin-antitoxin stability system -
JFX55_RS06195 (1198831) 1198831..1199052 - 222 WP_024216021.1 DUF987 domain-containing protein -
JFX55_RS06200 (1199121) 1199121..1199597 - 477 WP_137594896.1 RadC family protein -
JFX55_RS06205 (1199613) 1199613..1200098 - 486 WP_198790224.1 antirestriction protein -
JFX55_RS06210 (1200190) 1200190..1201011 - 822 WP_198790223.1 DUF932 domain-containing protein -
JFX55_RS06215 (1201232) 1201232..1201642 - 411 WP_000846713.1 hypothetical protein -
JFX55_RS06220 (1201658) 1201658..1202341 - 684 WP_000775500.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 1188677..1231940 43263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14161.13 Da        Isoelectric Point: 8.5220

>T204164 WP_062871540.1 NZ_CP075663:c1197664-1197287 [Escherichia coli]
MKTLPDTHVREASRSPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T204164 NZ_CP100651:523399-523749 [Bacillus halotolerans]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAGATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13647.28 Da        Isoelectric Point: 5.9573

>AT204164 WP_001285484.1 NZ_CP075663:c1198122-1197754 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPSTVTPCFGTRLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLGLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT204164 NZ_CP100651:523113-523394 [Bacillus halotolerans]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAACATTTCTTCCGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E1LVG0

References