Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704690..705333 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag MT_RS03175 Protein ID WP_003403187.1
Coordinates 704932..705333 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag MT_RS03170 Protein ID WP_003403184.1
Coordinates 704690..704935 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS03135 699972..700502 - 531 WP_003917320.1 two component system sensor kinase HK2 -
MT_RS03140 700486..701181 - 696 WP_003918099.1 two-component system response regulator TcrA -
MT_RS03145 701304..701615 + 312 WP_003403164.1 hypothetical protein -
MT_RS03150 701687..702637 + 951 WP_003900184.1 DUF1259 domain-containing protein -
MT_RS03155 702878..703462 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
MT_RS03160 703464..704177 + 714 Protein_627 IS607 family element transposase accessory protein TnpB -
MT_RS03165 704177..704645 + 469 Protein_628 hypothetical protein -
MT_RS03170 704690..704935 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MT_RS03175 704932..705333 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
MT_RS22005 705721..705888 - 168 WP_077385191.1 DUF3800 domain-containing protein -
MT_RS22010 705921..706118 - 198 WP_003403191.1 hypothetical protein -
MT_RS03190 706198..707355 - 1158 WP_003898524.1 hypothetical protein -
MT_RS03195 707407..707628 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MT_RS03200 707770..708375 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T20416 WP_003403187.1 NC_002755:704932-705333 [Mycobacterium tuberculosis CDC1551]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T20416 NC_002755:704932-705333 [Mycobacterium tuberculosis CDC1551]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT20416 WP_003403184.1 NC_002755:704690-704935 [Mycobacterium tuberculosis CDC1551]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT20416 NC_002755:704690-704935 [Mycobacterium tuberculosis CDC1551]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References