Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 10723..11270 Replicon plasmid pSTEC17_183-b
Accession NZ_CP075654
Organism Escherichia coli strain STEC17-183

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag JFX43_RS25450 Protein ID WP_001384452.1
Coordinates 10992..11270 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID B7LIH2
Locus tag JFX43_RS25445 Protein ID WP_012605119.1
Coordinates 10723..10992 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX43_RS25420 (JFX43_025420) 6500..7567 - 1068 WP_001536598.1 hypothetical protein -
JFX43_RS25425 (JFX43_025425) 8027..8731 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
JFX43_RS25430 (JFX43_025430) 8921..9424 + 504 WP_016232763.1 hypothetical protein -
JFX43_RS25440 (JFX43_025440) 10267..10614 + 348 Protein_14 recombinase family protein -
JFX43_RS25445 (JFX43_025445) 10723..10992 + 270 WP_012605119.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
JFX43_RS25450 (JFX43_025450) 10992..11270 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
JFX43_RS25455 (JFX43_025455) 11305..11463 + 159 Protein_17 3'-5' exonuclease -
JFX43_RS25460 (JFX43_025460) 11744..12196 + 453 WP_000670961.1 acyltransferase -
JFX43_RS25465 (JFX43_025465) 12247..13521 - 1275 Protein_19 Tn3 family transposase -
JFX43_RS25470 (JFX43_025470) 13627..14783 + 1157 WP_089538410.1 IS3-like element IS600 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..106915 106915
- inside IScluster/Tn - - 8027..17249 9222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T204150 WP_001384452.1 NZ_CP075654:10992-11270 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T204150 NZ_CP100601:813373-813783 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATTCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10200.51 Da        Isoelectric Point: 8.8735

>AT204150 WP_012605119.1 NZ_CP075654:10723-10992 [Escherichia coli]
MTQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLSHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT204150 NZ_CP100601:813126-813392 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0A0GNA3

References