Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4094952..4095577 Replicon chromosome
Accession NZ_CP075652
Organism Escherichia coli strain STEC17-183

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JFX43_RS19870 Protein ID WP_000911330.1
Coordinates 4095179..4095577 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JFX43_RS19865 Protein ID WP_000450524.1
Coordinates 4094952..4095179 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX43_RS19840 (4090755) 4090755..4091225 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JFX43_RS19845 (4091225) 4091225..4091797 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JFX43_RS19850 (4091943) 4091943..4092821 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JFX43_RS19855 (4092838) 4092838..4093872 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
JFX43_RS19860 (4094085) 4094085..4094798 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JFX43_RS19865 (4094952) 4094952..4095179 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JFX43_RS19870 (4095179) 4095179..4095577 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
JFX43_RS19875 (4095724) 4095724..4096587 + 864 WP_001267498.1 neutral zinc metallopeptidase -
JFX43_RS19880 (4096602) 4096602..4098617 + 2016 WP_032330806.1 tRNA cytosine(34) acetyltransferase TmcA -
JFX43_RS19885 (4098691) 4098691..4099389 + 699 WP_000679812.1 esterase -
JFX43_RS19890 (4099499) 4099499..4099699 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T204133 WP_000911330.1 NZ_CP075652:4095179-4095577 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T204133 NZ_CP100546:65466-65618 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT204133 WP_000450524.1 NZ_CP075652:4094952-4095179 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT204133 NZ_CP100546:c65411-65354 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References