Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3019966..3020552 Replicon chromosome
Accession NZ_CP075652
Organism Escherichia coli strain STEC17-183

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag JFX43_RS14580 Protein ID WP_042014162.1
Coordinates 3019966..3020196 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag JFX43_RS14585 Protein ID WP_000593555.1
Coordinates 3020193..3020552 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX43_RS14570 (3016003) 3016003..3018738 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
JFX43_RS14575 (3018738) 3018738..3019862 + 1125 WP_001216257.1 ABC transporter permease -
JFX43_RS14580 (3019966) 3019966..3020196 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
JFX43_RS14585 (3020193) 3020193..3020552 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JFX43_RS14590 (3020672) 3020672..3021073 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
JFX43_RS14595 (3021079) 3021079..3021885 - 807 WP_032331057.1 nickel import ATP-binding protein NikE -
JFX43_RS14600 (3021882) 3021882..3022646 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
JFX43_RS14605 (3022646) 3022646..3023479 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
JFX43_RS14610 (3023476) 3023476..3024420 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T204128 WP_042014162.1 NZ_CP075652:3019966-3020196 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T204128 NZ_CP100544:c4100570-4100220 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT204128 WP_000593555.1 NZ_CP075652:3020193-3020552 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT204128 NZ_CP100544:c4100815-4100564 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References