Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4502470..4503065 Replicon chromosome
Accession NZ_CP075649
Organism Escherichia coli strain STEC17-190

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag JFX56_RS21565 Protein ID WP_000239579.1
Coordinates 4502470..4502820 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag JFX56_RS21570 Protein ID WP_001223208.1
Coordinates 4502814..4503065 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX56_RS21545 (4497746) 4497746..4498768 - 1023 WP_001296689.1 ABC transporter permease -
JFX56_RS21550 (4498782) 4498782..4500284 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
JFX56_RS21555 (4500594) 4500594..4501550 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JFX56_RS21560 (4501860) 4501860..4502390 + 531 WP_136755751.1 inorganic diphosphatase -
JFX56_RS21565 (4502470) 4502470..4502820 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
JFX56_RS21570 (4502814) 4502814..4503065 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JFX56_RS21575 (4503278) 4503278..4503619 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JFX56_RS21580 (4503622) 4503622..4507401 - 3780 WP_136755752.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T204112 WP_000239579.1 NZ_CP075649:c4502820-4502470 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T204112 NZ_CP100544:189559-189666 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT204112 WP_001223208.1 NZ_CP075649:c4503065-4502814 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT204112 NZ_CP100544:c189502-189445 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References