Detailed information of TA system TA204111

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4405577..4406375
• Replicon: chromosome
• Accession: NZ_CP075649
• Organism: Escherichia coli strain STEC17-190

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1X1M0U2
• Locus tag: JFX56_RS21065
• Protein ID: WP_000854919.1
• Coordinates: 4405577..4405954 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JFX56_RS21070
• Protein ID: WP_063114613.1
• Coordinates: 4406001..4406375 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFX56_RS21030 (4400607)	4400607..4401380	+	774	WP_000157137.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
JFX56_RS21035 (4401373)	4401373..4402290	+	918	WP_000361918.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
JFX56_RS21040 (4402804)	4402804..4403466	-	663	WP_000357928.1	hypothetical protein	-
JFX56_RS21045 (4403539)	4403539..4404180	-	642	Protein_4146	integrase arm-type DNA-binding domain-containing protein	-
JFX56_RS21050 (4404647)	4404647..4404790	-	144	Protein_4147	hypothetical protein	-
JFX56_RS21055 (4404875)	4404875..4405072	-	198	WP_001327226.1	DUF957 domain-containing protein	-
JFX56_RS21060 (4405092)	4405092..4405580	-	489	WP_000777664.1	DUF5983 family protein	-
JFX56_RS21065 (4405577)	4405577..4405954	-	378	WP_000854919.1	TA system toxin CbtA family protein	Toxin
JFX56_RS21070 (4406001)	4406001..4406375	-	375	WP_063114613.1	type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA	Antitoxin
JFX56_RS21075 (4406455)	4406455..4406676	-	222	WP_000692350.1	DUF987 domain-containing protein	-
JFX56_RS21080 (4406763)	4406763..4407239	-	477	WP_001186725.1	RadC family protein	-
JFX56_RS21085 (4407255)	4407255..4407734	-	480	WP_000706981.1	antirestriction protein	-
JFX56_RS21090 (4407834)	4407834..4407974	+	141	WP_000997937.1	hypothetical protein	-
JFX56_RS21095 (4408000)	4408000..4408818	-	819	WP_001175165.1	DUF932 domain-containing protein	-
JFX56_RS21100 (4408908)	4408908..4409141	-	234	WP_001278293.1	DUF905 family protein	-
JFX56_RS21105 (4409147)	4409147..4409824	-	678	WP_001097302.1	hypothetical protein	-
JFX56_RS21110 (4409972)	4409972..4410652	-	681	WP_001282921.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	papH / papC / papD	4400607..4460037	59430

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14037.97 Da
• Isoelectric Point: 7.9086

>T204111 WP_000854919.1 NZ_CP075649:c4405954-4405577 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T204111 NZ_CP100544:189076-189183 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13626.41 Da
• Isoelectric Point: 5.5051

>AT204111 WP_063114613.1 NZ_CP075649:c4406375-4406001 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTLAPAITS

Nucleotide

• Length: 375 bp

>AT204111 NZ_CP100544:c189018-188962 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A1X1M0U2