Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3942103..3942938 | Replicon | chromosome |
| Accession | NZ_CP075649 | ||
| Organism | Escherichia coli strain STEC17-190 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | JFX56_RS18975 | Protein ID | WP_000854828.1 |
| Coordinates | 3942103..3942480 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | JFX56_RS18980 | Protein ID | WP_001285572.1 |
| Coordinates | 3942570..3942938 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX56_RS18945 (3937362) | 3937362..3938318 | + | 957 | WP_000121333.1 | molybdenum cofactor insertion chaperone PaoD | - |
| JFX56_RS18950 (3938369) | 3938369..3938707 | + | 339 | Protein_3737 | LysR substrate-binding domain-containing protein | - |
| JFX56_RS18955 (3939044) | 3939044..3940363 | + | 1320 | WP_000144688.1 | site-specific integrase | - |
| JFX56_RS18960 (3940456) | 3940456..3941304 | - | 849 | WP_136755782.1 | DUF4942 domain-containing protein | - |
| JFX56_RS18965 (3941401) | 3941401..3941598 | - | 198 | WP_000772024.1 | DUF957 domain-containing protein | - |
| JFX56_RS18970 (3941618) | 3941618..3942106 | - | 489 | Protein_3741 | DUF5983 family protein | - |
| JFX56_RS18975 (3942103) | 3942103..3942480 | - | 378 | WP_000854828.1 | TA system toxin CbtA family protein | Toxin |
| JFX56_RS18980 (3942570) | 3942570..3942938 | - | 369 | WP_001285572.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| JFX56_RS18985 (3942988) | 3942988..3943635 | - | 648 | WP_000094921.1 | hypothetical protein | - |
| JFX56_RS18990 (3943654) | 3943654..3943875 | - | 222 | WP_000692303.1 | DUF987 domain-containing protein | - |
| JFX56_RS18995 (3943944) | 3943944..3944420 | - | 477 | WP_001186724.1 | RadC family protein | - |
| JFX56_RS19000 (3944436) | 3944436..3944918 | - | 483 | WP_000213707.1 | antirestriction protein | - |
| JFX56_RS19005 (3945007) | 3945007..3945825 | - | 819 | WP_001234691.1 | DUF932 domain-containing protein | - |
| JFX56_RS19010 (3945925) | 3945925..3946158 | - | 234 | WP_024210659.1 | DUF905 family protein | - |
| JFX56_RS19015 (3946237) | 3946237..3946692 | - | 456 | WP_044188993.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE | 3912948..3944918 | 31970 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13998.08 Da Isoelectric Point: 9.9962
>T204106 WP_000854828.1 NZ_CP075649:c3942480-3942103 [Escherichia coli]
MKTLPVLPGQSASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVKFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITRGKHPEAKR
MKTLPVLPGQSASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVKFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITRGKHPEAKR
Download Length: 378 bp
>T204106 NZ_CP100542:3925560-3925778 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13602.41 Da Isoelectric Point: 6.7386
>AT204106 WP_001285572.1 NZ_CP075649:c3942938-3942570 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTATPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTPEMKN
VSDTLPGTTHPDDNHDRPWWGLPCTATPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT204106 NZ_CP100542:3925159-3925533 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|