Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3745186..3745804 Replicon chromosome
Accession NZ_CP075649
Organism Escherichia coli strain STEC17-190

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JFX56_RS18065 Protein ID WP_001291435.1
Coordinates 3745586..3745804 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JFX56_RS18060 Protein ID WP_000344800.1
Coordinates 3745186..3745560 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX56_RS18050 (3740275) 3740275..3741468 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JFX56_RS18055 (3741491) 3741491..3744640 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
JFX56_RS18060 (3745186) 3745186..3745560 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JFX56_RS18065 (3745586) 3745586..3745804 + 219 WP_001291435.1 HHA domain-containing protein Toxin
JFX56_RS18070 (3745976) 3745976..3746527 + 552 WP_000102564.1 maltose O-acetyltransferase -
JFX56_RS18075 (3746643) 3746643..3747113 + 471 WP_000136192.1 YlaC family protein -
JFX56_RS18080 (3747277) 3747277..3748827 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JFX56_RS18085 (3748869) 3748869..3749222 - 354 WP_000878141.1 DUF1428 family protein -
JFX56_RS18095 (3749601) 3749601..3749912 + 312 WP_000409911.1 MGMT family protein -
JFX56_RS18100 (3749943) 3749943..3750515 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T204104 WP_001291435.1 NZ_CP075649:3745586-3745804 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T204104 NZ_CP100542:1837656-1837758 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT204104 WP_000344800.1 NZ_CP075649:3745186-3745560 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT204104 NZ_CP100542:c1837765-1837620 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References