Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2473339..2473865 | Replicon | chromosome |
| Accession | NZ_CP075649 | ||
| Organism | Escherichia coli strain STEC17-190 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | JFX56_RS11855 | Protein ID | WP_000323025.1 |
| Coordinates | 2473578..2473865 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | JFX56_RS11850 | Protein ID | WP_000534858.1 |
| Coordinates | 2473339..2473578 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX56_RS24780 (2469348) | 2469348..2469497 | + | 150 | WP_180302674.1 | protein YdfW | - |
| JFX56_RS11825 (2469912) | 2469912..2471525 | - | 1614 | WP_001499133.1 | IS66 family transposase | - |
| JFX56_RS11830 (2471556) | 2471556..2471906 | - | 351 | WP_000624684.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| JFX56_RS11835 (2471903) | 2471903..2472328 | - | 426 | WP_000422722.1 | transposase | - |
| JFX56_RS11840 (2472474) | 2472474..2472806 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| JFX56_RS11845 (2473009) | 2473009..2473314 | - | 306 | WP_001326990.1 | protein YdfV | - |
| JFX56_RS11850 (2473339) | 2473339..2473578 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| JFX56_RS11855 (2473578) | 2473578..2473865 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| JFX56_RS11860 (2473937) | 2473937..2474092 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| JFX56_RS11865 (2474309) | 2474309..2474560 | + | 252 | WP_000980994.1 | protein Rem | - |
| JFX56_RS11870 (2474627) | 2474627..2474905 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| JFX56_RS11875 (2474907) | 2474907..2475956 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| JFX56_RS11880 (2475970) | 2475970..2476722 | + | 753 | WP_001047135.1 | antitermination protein | - |
| JFX56_RS11885 (2477000) | 2477000..2477089 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| JFX56_RS11890 (2477144) | 2477144..2477356 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| JFX56_RS11895 (2477656) | 2477656..2477871 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| JFX56_RS11900 (2478235) | 2478235..2478405 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| JFX56_RS11905 (2478625) | 2478625..2478840 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2442624..2517956 | 75332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T204101 WP_000323025.1 NZ_CP075649:2473578-2473865 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T204101 NZ_CP100542:328999-329367 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT204101 WP_000534858.1 NZ_CP075649:2473339-2473578 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT204101 NZ_CP100542:328781-329002 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|