Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 830804..831636 Replicon chromosome
Accession NZ_CP075649
Organism Escherichia coli strain STEC17-190

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag JFX56_RS04020 Protein ID WP_000854753.1
Coordinates 830804..831178 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag JFX56_RS04025 Protein ID WP_001278232.1
Coordinates 831268..831636 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX56_RS03985 (825871) 825871..826470 + 600 WP_001250465.1 type II secretion system minor pseudopilin GspJ -
JFX56_RS03990 (826473) 826473..827450 + 978 WP_000633238.1 type II secretion system minor pseudopilin GspK -
JFX56_RS03995 (827447) 827447..828625 + 1179 WP_000094974.1 type II secretion system protein GspL -
JFX56_RS04000 (828627) 828627..829163 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
JFX56_RS04005 (829444) 829444..830013 - 570 WP_001290243.1 DUF4942 domain-containing protein -
JFX56_RS04010 (830110) 830110..830307 - 198 WP_000839281.1 DUF957 domain-containing protein -
JFX56_RS04015 (830319) 830319..830807 - 489 WP_000777541.1 DUF5983 family protein -
JFX56_RS04020 (830804) 830804..831178 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
JFX56_RS04025 (831268) 831268..831636 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JFX56_RS04030 (831799) 831799..832020 - 222 WP_000692303.1 DUF987 domain-containing protein -
JFX56_RS04035 (832083) 832083..832559 - 477 WP_001186710.1 RadC family protein -
JFX56_RS04040 (832571) 832571..833050 - 480 WP_000860065.1 antirestriction protein -
JFX56_RS04045 (833132) 833132..833950 - 819 WP_001234631.1 DUF932 domain-containing protein -
JFX56_RS04050 (834050) 834050..834283 - 234 WP_001119729.1 DUF905 family protein -
JFX56_RS04055 (834362) 834362..834817 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T204088 WP_000854753.1 NZ_CP075649:c831178-830804 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T204088 NZ_CP100530:2815050-2815157 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT204088 WP_001278232.1 NZ_CP075649:c831636-831268 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT204088 NZ_CP100530:c2815000-2814937 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References