Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49333..50131 Replicon chromosome
Accession NZ_CP075649
Organism Escherichia coli strain STEC17-190

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JFX56_RS00255 Protein ID WP_000854903.1
Coordinates 49333..49710 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JFX56_RS00260 Protein ID WP_001280956.1
Coordinates 49757..50131 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX56_RS00225 (44700) 44700..45623 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
JFX56_RS00230 (45734) 45734..46918 - 1185 WP_001172876.1 sugar efflux transporter -
JFX56_RS00235 (47347) 47347..47475 - 129 Protein_46 RhuM family protein -
JFX56_RS00240 (47709) 47709..48554 - 846 WP_198776735.1 DUF4942 domain-containing protein -
JFX56_RS00245 (48639) 48639..48836 - 198 WP_000839249.1 DUF957 domain-containing protein -
JFX56_RS00250 (48848) 48848..49336 - 489 WP_198776734.1 DUF5983 family protein -
JFX56_RS00255 (49333) 49333..49710 - 378 WP_000854903.1 TA system toxin CbtA family protein Toxin
JFX56_RS00260 (49757) 49757..50131 - 375 WP_001280956.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JFX56_RS00265 (50294) 50294..50515 - 222 WP_000692352.1 DUF987 domain-containing protein -
JFX56_RS00270 (50584) 50584..51060 - 477 WP_001186725.1 RadC family protein -
JFX56_RS00275 (51076) 51076..51561 - 486 WP_198776732.1 antirestriction protein -
JFX56_RS00280 (51616) 51616..52434 - 819 WP_044808380.1 DUF932 domain-containing protein -
JFX56_RS00285 (52524) 52524..52757 - 234 WP_001117559.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14338.30 Da        Isoelectric Point: 6.8528

>T204082 WP_000854903.1 NZ_CP075649:c49710-49333 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATDLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T204082 NZ_CP100530:2056893-2056996 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13706.46 Da        Isoelectric Point: 6.4757

>AT204082 WP_001280956.1 NZ_CP075649:c50131-49757 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS

Download         Length: 375 bp

>AT204082 NZ_CP100530:c2057034-2056763 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References