Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 5954..6441 Replicon plasmid pS19_141-b
Accession NZ_CP075642
Organism Escherichia coli strain S19-141

Toxin (Protein)


Gene name TsxA Uniprot ID -
Locus tag JFX59_RS25205 Protein ID WP_086217910.1
Coordinates 5954..6208 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag JFX59_RS25210 Protein ID WP_047082009.1
Coordinates 6205..6441 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX59_RS25940 2105..2257 + 153 Protein_1 DUF5431 family protein -
JFX59_RS25170 (JFX59_025170) 2202..2324 + 123 WP_223202818.1 Hok/Gef family protein -
JFX59_RS25175 (JFX59_025175) 2474..3070 + 597 WP_000125165.1 ProQ/FINO family protein -
JFX59_RS25180 (JFX59_025180) 3088..3372 - 285 WP_001542021.1 hypothetical protein -
JFX59_RS25185 (JFX59_025185) 3451..4116 - 666 WP_000532148.1 division plane positioning ATPase MipZ -
JFX59_RS25190 (JFX59_025190) 4620..4949 + 330 WP_047082006.1 hypothetical protein -
JFX59_RS25195 (JFX59_025195) 5119..5415 + 297 WP_042968292.1 type II toxin-antitoxin system RelE/ParE family toxin -
JFX59_RS25200 (JFX59_025200) 5417..5701 + 285 WP_047082007.1 putative addiction module antidote protein -
JFX59_RS25205 (JFX59_025205) 5954..6208 + 255 WP_086217910.1 hypothetical protein Toxin
JFX59_RS25210 (JFX59_025210) 6205..6441 + 237 WP_047082009.1 transcriptional regulator Antitoxin
JFX59_RS25215 (JFX59_025215) 6453..6599 + 147 WP_155953439.1 hypothetical protein -
JFX59_RS25220 (JFX59_025220) 7153..7479 + 327 WP_032716095.1 hypothetical protein -
JFX59_RS25225 (JFX59_025225) 7520..7729 + 210 WP_032716096.1 hypothetical protein -
JFX59_RS25230 (JFX59_025230) 7827..8051 + 225 WP_000814383.1 hypothetical protein -
JFX59_RS25235 (JFX59_025235) 8103..8360 + 258 WP_042968288.1 hypothetical protein -
JFX59_RS25240 (JFX59_025240) 8354..8605 + 252 WP_022645142.1 transcriptional regulator -
JFX59_RS25245 (JFX59_025245) 9143..9448 + 306 WP_072096363.1 hypothetical protein -
JFX59_RS25250 (JFX59_025250) 9754..10041 + 288 WP_000606467.1 hypothetical protein -
JFX59_RS25255 (JFX59_025255) 10469..10702 + 234 WP_000093744.1 hypothetical protein -
JFX59_RS25260 (JFX59_025260) 10775..11080 + 306 WP_047081935.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..42892 42892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9835.34 Da        Isoelectric Point: 9.9839

>T204080 WP_086217910.1 NZ_CP075642:5954-6208 [Escherichia coli]
MRKNKGRLTYYLEISDKKYHFVKKISSYSKEYTEGKTKTTKRTLSELVFNESEVGAIDFTKNGLRPVDKNILLTMMKECK
ESDT

Download         Length: 255 bp

>T204080 NZ_CP075642:5954-6208 [Escherichia coli]
ATGAGAAAAAACAAAGGACGATTGACTTATTATCTTGAAATAAGTGATAAAAAATATCATTTTGTAAAAAAAATAAGCAG
CTATTCAAAGGAGTATACAGAAGGAAAAACTAAAACAACAAAGAGAACGTTAAGTGAACTGGTTTTTAATGAAAGCGAGG
TTGGGGCAATAGATTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGATGAAAGAATGTAAG
GAGAGTGATACATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8822.04 Da        Isoelectric Point: 7.8562

>AT204080 WP_047082009.1 NZ_CP075642:6205-6441 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPDYVLCKRNSDSGNN

Download         Length: 237 bp

>AT204080 NZ_CP075642:6205-6441 [Escherichia coli]
ATGACCATTGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATAGGTCTTACTCAGACAGAGTGCGGTGAAAT
TTTTGGTGTAGGTTTAAGTACATGGCAGAAAAAGGAAGCAAAAACCCACAACCAGTTAAATTTGTCCAAAGGTGAATTTG
AGTACCTGTTATTGCTTGCAGGGGAACACCCTGATTATGTGCTTTGTAAAAGGAATTCTGATTCTGGAAATAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References