Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4231122..4231776 Replicon chromosome
Accession NZ_CP075640
Organism Escherichia coli strain S19-141

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag JFX59_RS20435 Protein ID WP_198779896.1
Coordinates 4231369..4231776 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JFX59_RS20430 Protein ID WP_000354046.1
Coordinates 4231122..4231388 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX59_RS20405 (4226291) 4226291..4227034 + 744 WP_001436959.1 SDR family oxidoreductase -
JFX59_RS20410 (4227091) 4227091..4228524 - 1434 WP_001342496.1 6-phospho-beta-glucosidase BglA -
JFX59_RS20415 (4228569) 4228569..4228880 + 312 WP_001182947.1 N(4)-acetylcytidine aminohydrolase -
JFX59_RS20420 (4229044) 4229044..4229703 + 660 WP_000250274.1 hemolysin III family protein -
JFX59_RS20425 (4229899) 4229899..4230879 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
JFX59_RS20430 (4231122) 4231122..4231388 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JFX59_RS20435 (4231369) 4231369..4231776 + 408 WP_198779896.1 protein YgfX Toxin
JFX59_RS20440 (4231816) 4231816..4232337 - 522 WP_001055874.1 flavodoxin FldB -
JFX59_RS20445 (4232449) 4232449..4233345 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JFX59_RS20450 (4233370) 4233370..4234080 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JFX59_RS20455 (4234086) 4234086..4235819 + 1734 WP_000813168.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16045.99 Da        Isoelectric Point: 11.5202

>T204070 WP_198779896.1 NZ_CP075640:4231369-4231776 [Escherichia coli]
VVLWQSDLRISWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T204070 NZ_CP100526:c50448-50170 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT204070 WP_000354046.1 NZ_CP075640:4231122-4231388 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT204070 NZ_CP100526:c50717-50448 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References