Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3241294..3242095 | Replicon | chromosome |
| Accession | NZ_CP075640 | ||
| Organism | Escherichia coli strain S19-141 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0H0JYG3 |
| Locus tag | JFX59_RS15640 | Protein ID | WP_001094432.1 |
| Coordinates | 3241294..3241671 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0P7NA60 |
| Locus tag | JFX59_RS15645 | Protein ID | WP_001380152.1 |
| Coordinates | 3241718..3242095 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX59_RS15615 (3236659) | 3236659..3237582 | - | 924 | WP_000535960.1 | carboxylate/amino acid/amine transporter | - |
| JFX59_RS15620 (3237693) | 3237693..3238878 | - | 1186 | Protein_3057 | sugar efflux transporter | - |
| JFX59_RS25810 (3239275) | 3239275..3239436 | - | 162 | Protein_3058 | RhuM family protein | - |
| JFX59_RS15625 (3239670) | 3239670..3240515 | - | 846 | WP_001280530.1 | DUF4942 domain-containing protein | - |
| JFX59_RS15630 (3240600) | 3240600..3240797 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| JFX59_RS15635 (3240809) | 3240809..3241297 | - | 489 | WP_033884750.1 | DUF5983 family protein | - |
| JFX59_RS15640 (3241294) | 3241294..3241671 | - | 378 | WP_001094432.1 | TA system toxin CbtA family protein | Toxin |
| JFX59_RS15645 (3241718) | 3241718..3242095 | - | 378 | WP_001380152.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| JFX59_RS15650 (3242171) | 3242171..3242392 | - | 222 | WP_000692313.1 | DUF987 domain-containing protein | - |
| JFX59_RS15655 (3242461) | 3242461..3242937 | - | 477 | WP_033884753.1 | RadC family protein | - |
| JFX59_RS15660 (3242952) | 3242952..3243425 | - | 474 | WP_000855069.1 | antirestriction protein | - |
| JFX59_RS15665 (3243559) | 3243559..3243759 | - | 201 | WP_001367430.1 | hypothetical protein | - |
| JFX59_RS15670 (3243759) | 3243759..3244580 | - | 822 | WP_001241714.1 | DUF932 domain-containing protein | - |
| JFX59_RS25815 (3244758) | 3244758..3244847 | - | 90 | WP_112031555.1 | DUF905 family protein | - |
| JFX59_RS15680 (3244983) | 3244983..3245444 | - | 462 | WP_000581501.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14136.99 Da Isoelectric Point: 6.4729
>T204067 WP_001094432.1 NZ_CP075640:c3241671-3241294 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T204067 NZ_CP100525:c4003007-4002720 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13679.52 Da Isoelectric Point: 5.8682
>AT204067 WP_001380152.1 NZ_CP075640:c3242095-3241718 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT204067 NZ_CP100525:c4002733-4002431 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H0JYG3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0P7NA60 |