Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2700696..2701494 Replicon chromosome
Accession NZ_CP075640
Organism Escherichia coli strain S19-141

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0P7PH46
Locus tag JFX59_RS13155 Protein ID WP_000854896.1
Coordinates 2701117..2701494 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A234XUW5
Locus tag JFX59_RS13150 Protein ID WP_024175300.1
Coordinates 2700696..2701070 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX59_RS13125 (2698040) 2698040..2698273 + 234 WP_001117568.1 DUF905 family protein -
JFX59_RS13130 (2698364) 2698364..2699182 + 819 WP_033884686.1 DUF932 domain-containing protein -
JFX59_RS13135 (2699272) 2699272..2699757 + 486 WP_000214386.1 antirestriction protein -
JFX59_RS13140 (2699773) 2699773..2700249 + 477 WP_001186727.1 RadC family protein -
JFX59_RS13145 (2700312) 2700312..2700533 + 222 WP_000692358.1 DUF987 domain-containing protein -
JFX59_RS13150 (2700696) 2700696..2701070 + 375 WP_024175300.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JFX59_RS13155 (2701117) 2701117..2701494 + 378 WP_000854896.1 TA system toxin CbtA family protein Toxin
JFX59_RS13160 (2701491) 2701491..2701979 + 489 WP_000761662.1 DUF5983 family protein -
JFX59_RS13165 (2701991) 2701991..2702188 + 198 WP_000839256.1 DUF957 domain-containing protein -
JFX59_RS13170 (2702273) 2702273..2703139 + 867 WP_000014510.1 DUF4942 domain-containing protein -
JFX59_RS13175 (2703211) 2703211..2703474 + 264 WP_024213490.1 type II toxin-antitoxin system ParD family antitoxin -
JFX59_RS13180 (2703471) 2703471..2703797 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JFX59_RS26030 (2704260) 2704260..2704419 + 160 Protein_2590 integrase -
JFX59_RS13185 (2704679) 2704679..2706217 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2658286..2714030 55744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14210.19 Da        Isoelectric Point: 7.2920

>T204064 WP_000854896.1 NZ_CP075640:2701117-2701494 [Escherichia coli]
MKTLSDTHVREASRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T204064 NZ_CP100525:3415707-3415925 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13664.42 Da        Isoelectric Point: 6.4757

>AT204064 WP_024175300.1 NZ_CP075640:2700696-2701070 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVKPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHSVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS

Download         Length: 375 bp

>AT204064 NZ_CP100525:3415307-3415681 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGATT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7PH46

Antitoxin

Source ID Structure
AlphaFold DB A0A234XUW5

References