Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2510180..2510775 Replicon chromosome
Accession NZ_CP075640
Organism Escherichia coli strain S19-141

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag JFX59_RS12220 Protein ID WP_000239579.1
Coordinates 2510180..2510530 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag JFX59_RS12225 Protein ID WP_001223208.1
Coordinates 2510524..2510775 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX59_RS12200 (2505626) 2505626..2506648 - 1023 WP_001368084.1 ABC transporter permease -
JFX59_RS12205 (2506662) 2506662..2508140 - 1479 WP_169300737.1 sugar ABC transporter ATP-binding protein -
JFX59_RS12210 (2508304) 2508304..2509260 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JFX59_RS12215 (2509570) 2509570..2510100 + 531 WP_000055075.1 inorganic diphosphatase -
JFX59_RS12220 (2510180) 2510180..2510530 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
JFX59_RS12225 (2510524) 2510524..2510775 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JFX59_RS12230 (2510987) 2510987..2511328 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JFX59_RS12235 (2511331) 2511331..2515110 - 3780 WP_024213559.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T204063 WP_000239579.1 NZ_CP075640:c2510530-2510180 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T204063 NZ_CP100525:2588221-2588328 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT204063 WP_001223208.1 NZ_CP075640:c2510775-2510524 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT204063 NZ_CP100525:c2588174-2588108 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References