Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3531118..3531919 | Replicon | chromosome |
| Accession | NZ_CP075632 | ||
| Organism | Escherichia coli strain 2018-166 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0H0JYG3 |
| Locus tag | JFX80_RS17420 | Protein ID | WP_001094432.1 |
| Coordinates | 3531118..3531495 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0P7NA60 |
| Locus tag | JFX80_RS17425 | Protein ID | WP_001380152.1 |
| Coordinates | 3531542..3531919 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX80_RS17395 (3526484) | 3526484..3527407 | - | 924 | WP_000535960.1 | carboxylate/amino acid/amine transporter | - |
| JFX80_RS17400 (3527518) | 3527518..3528702 | - | 1185 | WP_001172876.1 | sugar efflux transporter | - |
| JFX80_RS27365 (3529099) | 3529099..3529260 | - | 162 | Protein_3419 | RhuM family protein | - |
| JFX80_RS17405 (3529494) | 3529494..3530339 | - | 846 | WP_001280530.1 | DUF4942 domain-containing protein | - |
| JFX80_RS17410 (3530424) | 3530424..3530621 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| JFX80_RS17415 (3530633) | 3530633..3531121 | - | 489 | WP_032308658.1 | DUF5983 family protein | - |
| JFX80_RS17420 (3531118) | 3531118..3531495 | - | 378 | WP_001094432.1 | TA system toxin CbtA family protein | Toxin |
| JFX80_RS17425 (3531542) | 3531542..3531919 | - | 378 | WP_001380152.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| JFX80_RS17430 (3531995) | 3531995..3532216 | - | 222 | WP_000692313.1 | DUF987 domain-containing protein | - |
| JFX80_RS17435 (3532285) | 3532285..3532761 | - | 477 | WP_001186704.1 | RadC family protein | - |
| JFX80_RS17440 (3532776) | 3532776..3533249 | - | 474 | WP_000855069.1 | antirestriction protein | - |
| JFX80_RS17445 (3533383) | 3533383..3533583 | - | 201 | WP_001367430.1 | hypothetical protein | - |
| JFX80_RS17450 (3533583) | 3533583..3534404 | - | 822 | WP_001241714.1 | DUF932 domain-containing protein | - |
| JFX80_RS27370 (3534582) | 3534582..3534671 | - | 90 | WP_112031555.1 | DUF905 family protein | - |
| JFX80_RS17460 (3534807) | 3534807..3535268 | - | 462 | WP_000581501.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14136.99 Da Isoelectric Point: 6.4729
>T204031 WP_001094432.1 NZ_CP075632:c3531495-3531118 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T204031 NZ_CP100515:612219-612560 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCAGCGGGCTGCGAAACTCTATCTGTCGCCCGTGGCTGTCTGGCAAATGCTGCTTGC
ACGCCTGCTAGAACAACATCATGGCCTGATTCTAAACGATACACCTTTCAGCGATGAGGCGGTTATTCAGGAACACATCA
ATGCTGGTATCAACCTAGCTGATGCAGTGAACTTTCTGATGGAAAAGTACGAGCTGGTCCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA
ATGAAAACTCTACCTGCAACAACTCAGCGGGCTGCGAAACTCTATCTGTCGCCCGTGGCTGTCTGGCAAATGCTGCTTGC
ACGCCTGCTAGAACAACATCATGGCCTGATTCTAAACGATACACCTTTCAGCGATGAGGCGGTTATTCAGGAACACATCA
ATGCTGGTATCAACCTAGCTGATGCAGTGAACTTTCTGATGGAAAAGTACGAGCTGGTCCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13679.52 Da Isoelectric Point: 5.8682
>AT204031 WP_001380152.1 NZ_CP075632:c3531919-3531542 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT204031 NZ_CP100515:611857-612198 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGGCTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATATGGCTGACCGAGCCAGCATTACCGGTAAATTCAGTAACGCAGAATATT
TGAAGTTGGTTGAAATATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCAT
GCCCACTGCGTCACCCTGTACCACAACGGTTTTACCTGCGAAGCCGATACGCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGGCTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATATGGCTGACCGAGCCAGCATTACCGGTAAATTCAGTAACGCAGAATATT
TGAAGTTGGTTGAAATATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCAT
GCCCACTGCGTCACCCTGTACCACAACGGTTTTACCTGCGAAGCCGATACGCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H0JYG3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0P7NA60 |