Detailed information of TA system TA020402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1577010..1577657
• Replicon: chromosome
• Accession: NC_002754
• Organism: Sulfolobus solfataricus P2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SSO_RS08385
• Protein ID: WP_009990357.1
• Coordinates: 1577010..1577282 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E3K976
• Locus tag: SSO_RS08390
• Protein ID: WP_009990356.1
• Coordinates: 1577397..1577657 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSO_RS08360 (SSO1735)	1572325..1573376	-	1052	Protein_1662	ISH3-like element ISC1359 family transposase	-
SSO_RS08365 (SSO1734)	1573480..1574229	+	750	Protein_1663	GDP-mannose 4,6-dehydratase	-
SSO_RS08380 (SSO1739)	1575540..1576487	-	948	WP_009990359.1	ATP/GTP-binding protein	-
SSO_RS08385 (SSO8813)	1577010..1577282	-	273	WP_009990357.1	PIN domain-containing protein	Toxin
SSO_RS08390	1577397..1577657	-	261	WP_009990356.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SSO_RS16370	1578344..1578505	+	162	WP_009990355.1	hypothetical protein	-
SSO_RS08395 (SSO1740)	1578607..1579065	+	459	WP_009990354.1	hypothetical protein	-
SSO_RS08400 (SSO1741)	1579814..1580320	-	507	WP_014511696.1	thiosulfate:quinone oxidoreductase small subunit	-
SSO_RS08405 (SSO1742)	1580326..1580868	-	543	WP_009990352.1	thiosulfate:quinone oxidoreductase large subunit	-
SSO_RS08410 (SSO1744)	1581176..1582051	-	876	Protein_1671	transposase	-
SSO_RS08415	1582412..1582645	+	234	WP_009993269.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (20-82)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10475.34 Da
• Isoelectric Point: 9.7534

>T20402 WP_009990357.1 NC_002754:c1577282-1577010 [Saccharolobus solfataricus P2]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Nucleotide

• Length: 273 bp

>T20402 NC_002754:c1577282-1577010 [Saccharolobus solfataricus P2]
ATGAGGTTATTTACATTATCAAAAAAGAAGTATAATGTAAAATTTGAGGATACAATTGATTTCTTAGATAAGATAATACT
TCCTTATACAATTATACTGCCAATCAACTCTCATGATTATGAAAAAGCAAAGGGGATAATGATAAGTAAGACTTTAAAAC
CGTCTGATGCTTTCCACGTAGCTGTAATGATAAATAATTCAATAAAAAAGATAGTAAGTGAGGATTCAGATTTCGATAAA
ATTAATGGAATAGAAAGGATTTGGGTAAAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9842.51 Da
• Isoelectric Point: 5.2456

>AT20402 WP_009990356.1 NC_002754:c1577657-1577397 [Saccharolobus solfataricus P2]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Nucleotide

• Length: 261 bp

>AT20402 NC_002754:c1577657-1577397 [Saccharolobus solfataricus P2]
TTGACCCTAAAGATTGAAGTTGGAAAGAAAGGATATATAATAATCCCTAAGACTGTTAGGGATCTTCTTGAAATAAAGGA
GGGAGATATATTAATCCTAAGAGTCGAAGATGGTAAAATTGTTCTTGAGCCTGAAAGAAAGGTAAGTTTTGATGACTTAA
AAAAGAAGATGGAGGAACATAGTGCTAAAATCTCATATGCAAATAAGGCTAAACTTGGAGATTTAATTAACGTTAGTTTA
GAGGAGGAATTCGATAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E3K976