Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1340396..1340996 Replicon chromosome
Accession NC_002754
Organism Sulfolobus solfataricus P2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SSO_RS07250 Protein ID WP_048054229.1
Coordinates 1340607..1340996 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A157T1M9
Locus tag SSO_RS07245 Protein ID WP_048054328.1
Coordinates 1340396..1340620 (+) Length 75 a.a.

Genomic Context

SSO_RS17475SSO_RS07245SSO_RS07250SSO_RS07255SSO_RS07265SSO_RS07270SSO_RS17025SSO_RS07220SSO_RS07225SSO_RS07230SSO_RS07235SSO_RS07240SSO_RS07260
Location: 1337487..1337657 (171 bp)
Type: Others
Protein ID: Protein_1427
Location: 1340396..1340620 (225 bp)
Type: Antitoxin
Protein ID: WP_048054328.1
Location: 1340607..1340996 (390 bp)
Type: Toxin
Protein ID: WP_048054229.1
Location: 1341997..1342947 (951 bp)
Type: Others
Protein ID: WP_010923426.1
Location: 1343471..1344444 (974 bp)
Type: Others
Protein ID: Protein_1435
Location: 1344586..1345083 (498 bp)
Type: Others
Protein ID: WP_014511660.1
Location: 1345479..1345624 (146 bp)
Type: Others
Protein ID: Protein_1437
Location: 1336464..1336907 (444 bp)
Type: Others
Protein ID: WP_010923418.1
Location: 1336991..1337419 (429 bp)
Type: Others
Protein ID: WP_010923419.1
Location: 1337632..1338528 (897 bp)
Type: Others
Protein ID: Protein_1428
Location: 1338701..1339660 (960 bp)
Type: Others
Protein ID: WP_010923364.1
Location: 1339758..1339922 (165 bp)
Type: Others
Protein ID: Protein_1430
Location: 1343008..1343346 (339 bp)
Type: Others
Protein ID: WP_010923427.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSO_RS07220 (SSO1478)1336464..1336907-444WP_010923418.1hypothetical protein-
SSO_RS07225 (SSO1479)1336991..1337419-429WP_010923419.1transposase-
SSO_RS174751337487..1337657+171Protein_1427transposase-
SSO_RS07230 (SSO1480)1337632..1338528-897Protein_1428ISH3-like element ISC1225 family transposase-
SSO_RS07235 (SSO1481)1338701..1339660-960WP_010923364.1IS5-like element ISC1234 family transposase-
SSO_RS07240 (SSO8189)1339758..1339922-165Protein_1430DUF4322 domain-containing protein-
SSO_RS072451340396..1340620+225WP_048054328.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SSO_RS07250 (SSO1483)1340607..1340996+390WP_048054229.1PIN domain-containing proteinToxin
SSO_RS07255 (SSO1484)1341997..1342947+951WP_010923426.1IS110-like element ISC1190 family transposase-
SSO_RS07260 (SSO1486)1343008..1343346-339WP_010923427.1hypothetical protein-
SSO_RS07265 (SSO1487)1343471..1344444+974Protein_1435IS5 family transposase-
SSO_RS07270 (SSO1489)1344586..1345083+498WP_014511660.1hypothetical protein-
SSO_RS170251345479..1345624+146Protein_1437IS630 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--1312127..134614134014
-insideIScluster/Tn--1333044..135247219428


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

SpoVT-AbrB domain

(4-45)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14446.03 Da        Isoelectric Point: 4.5625

>T20400 WP_048054229.1 NC_002754:1340607-1340996 [Saccharolobus solfataricus P2]
MIVVDTNVLIYATLEDSEFHTQSLEIIEGSDIIVPQIVVFEYIKVLSEIVQNLDFIKTKISELNNFVVVCEDLNTIALAL
RLLAELKLSLKDINDMIILTAAIKTNSSIATFDQKLRKIADKKGVKVLP

Download         Length: 390 bp

>T20400 NC_002754:1340607-1340996 [Saccharolobus solfataricus P2]
ATGATAGTAGTTGATACGAATGTCCTAATTTACGCCACTCTTGAAGACAGCGAATTTCATACTCAAAGTCTAGAGATAAT
TGAGGGATCAGACATAATAGTTCCCCAAATTGTAGTCTTCGAATACATAAAGGTACTATCTGAAATTGTACAGAACTTAG
ATTTCATAAAAACAAAAATCTCAGAGTTAAACAATTTTGTCGTTGTTTGCGAAGACCTTAATACTATAGCACTAGCGTTG
AGACTATTAGCAGAGTTAAAACTTTCACTGAAAGACATTAACGATATGATAATCTTAACCGCAGCAATTAAGACAAACAG
CTCCATAGCCACATTTGATCAGAAGCTTAGAAAGATTGCAGACAAGAAGGGAGTTAAAGTTTTGCCTTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8530.93 Da        Isoelectric Point: 8.5049

>AT20400 WP_048054328.1 NC_002754:1340396-1340620 [Saccharolobus solfataricus P2]
MISKVTRNFQVTIPYEIRKVLGIKEGDYIEFAIENGKVMIKPVRKVWSTIRLGREVTVEEIEEIASKAFKDDSS

Download         Length: 225 bp

>AT20400 NC_002754:1340396-1340620 [Saccharolobus solfataricus P2]
ATGATATCTAAGGTCACCAGGAACTTTCAAGTCACAATTCCTTATGAGATTAGAAAAGTGCTAGGAATAAAAGAGGGAGA
CTATATTGAGTTCGCAATAGAAAACGGTAAGGTCATGATAAAACCTGTTAGAAAAGTTTGGTCAACTATTAGACTTGGAA
GAGAAGTTACAGTGGAGGAGATTGAGGAAATCGCAAGTAAGGCCTTTAAAGATGATAGTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A157T1M9

References