Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3951257..3952055 | Replicon | chromosome |
| Accession | NZ_CP075627 | ||
| Organism | Escherichia coli strain P15-385 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | JFX93_RS19175 | Protein ID | WP_000854902.1 |
| Coordinates | 3951678..3952055 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A093DMQ4 |
| Locus tag | JFX93_RS19170 | Protein ID | WP_001280952.1 |
| Coordinates | 3951257..3951631 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX93_RS19140 (3948093) | 3948093..3948548 | + | 456 | WP_000581507.1 | IrmA family protein | - |
| JFX93_RS19145 (3948627) | 3948627..3948860 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| JFX93_RS19150 (3948960) | 3948960..3949778 | + | 819 | WP_001234626.1 | DUF932 domain-containing protein | - |
| JFX93_RS19155 (3949833) | 3949833..3950318 | + | 486 | WP_000849590.1 | antirestriction protein | - |
| JFX93_RS19160 (3950334) | 3950334..3950810 | + | 477 | WP_001186725.1 | RadC family protein | - |
| JFX93_RS19165 (3950873) | 3950873..3951094 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| JFX93_RS19170 (3951257) | 3951257..3951631 | + | 375 | WP_001280952.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JFX93_RS19175 (3951678) | 3951678..3952055 | + | 378 | WP_000854902.1 | TA system toxin CbtA family protein | Toxin |
| JFX93_RS19180 (3952052) | 3952052..3952540 | + | 489 | WP_000779175.1 | DUF5983 family protein | - |
| JFX93_RS19185 (3952552) | 3952552..3952749 | + | 198 | WP_000839261.1 | DUF957 domain-containing protein | - |
| JFX93_RS19190 (3952834) | 3952834..3953676 | + | 843 | WP_001280537.1 | DUF4942 domain-containing protein | - |
| JFX93_RS19195 (3954019) | 3954019..3954555 | - | 537 | WP_000942798.1 | GspM family type II secretion system protein YghD | - |
| JFX93_RS19200 (3954557) | 3954557..3955735 | - | 1179 | WP_000094987.1 | type II secretion system protein GspL | - |
| JFX93_RS19205 (3955732) | 3955732..3956709 | - | 978 | WP_000633193.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3877048..4013477 | 136429 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14307.29 Da Isoelectric Point: 7.2922
>T203999 WP_000854902.1 NZ_CP075627:3951678-3952055 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T203999 NZ_CP100500:4161299-4161517 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13719.50 Da Isoelectric Point: 6.6249
>AT203999 WP_001280952.1 NZ_CP075627:3951257-3951631 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT203999 NZ_CP100500:4160899-4161273 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|