Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3338707..3339332 Replicon chromosome
Accession NZ_CP075627
Organism Escherichia coli strain P15-385

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JFX93_RS16250 Protein ID WP_000911330.1
Coordinates 3338707..3339105 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JFX93_RS16255 Protein ID WP_000450524.1
Coordinates 3339105..3339332 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX93_RS16230 (3334614) 3334614..3334814 + 201 WP_000383836.1 YpfN family protein -
JFX93_RS16235 (3334895) 3334895..3335593 - 699 WP_000679812.1 esterase -
JFX93_RS16240 (3335667) 3335667..3337682 - 2016 WP_000829342.1 tRNA cytosine(34) acetyltransferase TmcA -
JFX93_RS16245 (3337697) 3337697..3338560 - 864 WP_001267508.1 neutral zinc metallopeptidase -
JFX93_RS16250 (3338707) 3338707..3339105 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
JFX93_RS16255 (3339105) 3339105..3339332 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JFX93_RS16260 (3339486) 3339486..3340199 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JFX93_RS16265 (3340412) 3340412..3341446 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
JFX93_RS16270 (3341463) 3341463..3342341 - 879 WP_001345767.1 4-hydroxy-tetrahydrodipicolinate synthase -
JFX93_RS16275 (3342487) 3342487..3343059 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JFX93_RS16280 (3343059) 3343059..3343529 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T203996 WP_000911330.1 NZ_CP075627:c3339105-3338707 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T203996 NZ_CP100500:3107686-3107793 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGAGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT203996 WP_000450524.1 NZ_CP075627:c3339332-3339105 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT203996 NZ_CP100500:c3107639-3107573 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References