Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1819315..1819794 Replicon chromosome
Accession NZ_CP075627
Organism Escherichia coli strain P15-385

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A234Y3J1
Locus tag JFX93_RS08660 Protein ID WP_001444087.1
Coordinates 1819315..1819602 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A234Y267
Locus tag JFX93_RS08665 Protein ID WP_001090455.1
Coordinates 1819606..1819794 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX93_RS08630 (1814527) 1814527..1814796 - 270 WP_000003742.1 excisionase -
JFX93_RS08635 (1814858) 1814858..1817260 - 2403 WP_135248649.1 exonuclease -
JFX93_RS08640 (1817353) 1817353..1817541 - 189 WP_000092782.1 DUF1482 family protein -
JFX93_RS08645 (1817538) 1817538..1817726 - 189 WP_000450222.1 cell division inhibition protein DicB -
JFX93_RS08650 (1818511) 1818511..1818879 - 369 WP_028985920.1 hypothetical protein -
JFX93_RS08655 (1818891) 1818891..1819043 - 153 WP_000380321.1 DUF1391 family protein -
JFX93_RS08660 (1819315) 1819315..1819602 - 288 WP_001444087.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JFX93_RS08665 (1819606) 1819606..1819794 - 189 WP_001090455.1 hypothetical protein Antitoxin
JFX93_RS08670 (1819824) 1819824..1820222 - 399 WP_000209117.1 helix-turn-helix domain-containing protein -
JFX93_RS08675 (1820339) 1820339..1820617 + 279 WP_000548554.1 YdaS family helix-turn-helix protein -
JFX93_RS08680 (1820601) 1820601..1821122 + 522 WP_000705386.1 toxin YdaT family protein -
JFX93_RS08685 (1821103) 1821103..1822068 + 966 WP_000054520.1 hypothetical protein -
JFX93_RS08690 (1822075) 1822075..1822815 + 741 WP_000790460.1 ATP-binding protein -
JFX93_RS08695 (1822845) 1822845..1823606 + 762 WP_180201617.1 DUF1627 domain-containing protein -
JFX93_RS08700 (1823639) 1823639..1823920 + 282 WP_072094476.1 DNA-binding protein -
JFX93_RS08705 (1823917) 1823917..1824222 + 306 WP_053294093.1 DUF4406 domain-containing protein -
JFX93_RS08710 (1824370) 1824370..1824552 + 183 WP_022581296.1 hypothetical protein -
JFX93_RS08715 (1824545) 1824545..1824721 + 177 WP_000753060.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2A / stx2B 1806271..1875173 68902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11014.71 Da        Isoelectric Point: 6.2118

>T203986 WP_001444087.1 NZ_CP075627:c1819602-1819315 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVATLSIE
IVSVVHARRQFPKQN

Download         Length: 288 bp

>T203986 NZ_CP100500:c956105-955728 [Escherichia coli]
ATGAAAACATTCCCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTTGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCAGTACCCGTTCTCAGTTAATCAGCAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGGCTGATGACCCGCAG
CCACTACCGAATGGTGAACAACATCACCCTGGGTAAACACTGTGAGGTGAAACCATGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7249.25 Da        Isoelectric Point: 8.6832

>AT203986 WP_001090455.1 NZ_CP075627:c1819794-1819606 [Escherichia coli]
MNTALSPMVSEFETIEQENSYNEWLRAKVAASLANPRPAIPHDEVERRMAERFAKMRKERSK

Download         Length: 189 bp

>AT203986 NZ_CP100500:c956529-956152 [Escherichia coli]
ATGTCAGACACACTCACCGGGACAACGCATCCCGACGACAATAACAATCTCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGGGCCGGTATCAGAAGCCGGT
TCAGCGACGCAGATGCGTATCACCTGGACCAGGCTTTTCCGCTGCTGATGAAACAGCTGGAGCTCATGCTCACCAGCGGT
GAACTCAGTCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAGGCCGACACCCTCGGCAGTTG
TGGTTACGTGTATATCGCCATTTATCCGACACCGGCAACACCCGGAACCACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A234Y3J1

Antitoxin

Source ID Structure
AlphaFold DB A0A234Y267

References