Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 38431..39050 | Replicon | plasmid p1207_3 |
| Accession | NZ_CP075607 | ||
| Organism | Enterococcus faecalis strain 1207/14 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | R3H4V2 |
| Locus tag | KKP64_RS17255 | Protein ID | WP_000241511.1 |
| Coordinates | 38431..38793 (-) | Length | 121 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | R3H5D1 |
| Locus tag | KKP64_RS17260 | Protein ID | WP_000245205.1 |
| Coordinates | 38787..39050 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKP64_RS17240 (33841) | 33841..35772 | - | 1932 | WP_002370258.1 | sucrose-specific PTS transporter subunit IIBC | - |
| KKP64_RS17245 (35963) | 35963..37402 | + | 1440 | WP_002367771.1 | sucrose-6-phosphate hydrolase | - |
| KKP64_RS17250 (37404) | 37404..38366 | + | 963 | WP_002367770.1 | LacI family DNA-binding transcriptional regulator | - |
| KKP64_RS17255 (38431) | 38431..38793 | - | 363 | WP_000241511.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KKP64_RS17260 (38787) | 38787..39050 | - | 264 | WP_000245205.1 | PbsX family transcriptional regulator | Antitoxin |
| KKP64_RS17265 (39227) | 39227..39847 | + | 621 | WP_021732893.1 | recombinase family protein | - |
| KKP64_RS17270 (39864) | 39864..40151 | + | 288 | WP_010708491.1 | hypothetical protein | - |
| KKP64_RS17275 (40145) | 40145..40369 | + | 225 | WP_010708492.1 | ultraviolet resistance protein UvrA repressor UvrC | - |
| KKP64_RS17280 (40430) | 40430..40639 | + | 210 | WP_002387638.1 | hypothetical protein | - |
| KKP64_RS17805 (40801) | 40801..40953 | + | 153 | WP_225850000.1 | DUF6440 family protein | - |
| KKP64_RS17290 (41380) | 41380..42708 | + | 1329 | WP_002387639.1 | ultraviolet resistance protein UvrA | - |
| KKP64_RS17295 (42705) | 42705..43055 | + | 351 | WP_002365943.1 | hypothetical protein | - |
| KKP64_RS17810 (43012) | 43012..43224 | + | 213 | WP_002365945.1 | hypothetical protein | - |
| KKP64_RS17300 (43315) | 43315..43416 | + | 102 | WP_002387930.1 | type I toxin-antitoxin system Fst family toxin | - |
| - (43456) | 43456..43558 | - | 103 | NuclAT_0 | - | - |
| - (43456) | 43456..43558 | - | 103 | NuclAT_0 | - | - |
| - (43456) | 43456..43558 | - | 103 | NuclAT_0 | - | - |
| - (43456) | 43456..43558 | - | 103 | NuclAT_0 | - | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..46461 | 46461 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13585.78 Da Isoelectric Point: 9.6107
>T203977 WP_000241511.1 NZ_CP075607:c38793-38431 [Enterococcus faecalis]
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF
Download Length: 363 bp
>T203977 NZ_CP100498:50536-51018 [Klebsiella michiganensis]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGTGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGTGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10059.46 Da Isoelectric Point: 5.1585
>AT203977 WP_000245205.1 NZ_CP075607:c39050-38787 [Enterococcus faecalis]
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW
Download Length: 264 bp
>AT203977 NZ_CP100498:50282-50548 [Klebsiella michiganensis]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTAGAGATTGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTAGAGATTGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|