Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 418425..418921 Replicon chromosome
Accession NZ_CP075604
Organism Enterococcus faecalis strain 1207/14

Toxin (Protein)


Gene name relE Uniprot ID R3GZA4
Locus tag KKP64_RS02075 Protein ID WP_002358470.1
Coordinates 418652..418921 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R3JPM7
Locus tag KKP64_RS02070 Protein ID WP_002413218.1
Coordinates 418425..418652 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKP64_RS02045 (414569) 414569..415099 + 531 WP_002358466.1 hypothetical protein -
KKP64_RS02050 (415114) 415114..415938 + 825 WP_002358467.1 hypothetical protein -
KKP64_RS02055 (416314) 416314..416577 + 264 WP_002358468.1 hypothetical protein -
KKP64_RS02060 (416570) 416570..417127 + 558 WP_002358242.1 hypothetical protein -
KKP64_RS02065 (417130) 417130..418365 + 1236 WP_002358469.1 MobP2 family relaxase -
KKP64_RS02070 (418425) 418425..418652 + 228 WP_002413218.1 DUF6290 family protein Antitoxin
KKP64_RS02075 (418652) 418652..418921 + 270 WP_002358470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KKP64_RS02080 (418988) 418988..420568 + 1581 WP_002404807.1 DUF3991 domain-containing protein -
KKP64_RS02085 (420585) 420585..421289 + 705 WP_010706734.1 hypothetical protein -
KKP64_RS02090 (421290) 421290..422135 + 846 WP_002358473.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 10.5395

>T203941 WP_002358470.1 NZ_CP075604:418652-418921 [Enterococcus faecalis]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTANPREHGKALSANRAGQWRYRIGNYRVIVEIEDERLVVTAIQV
GHRRNVYDK

Download         Length: 270 bp

>T203941 NZ_CP100486:2202217-2202320 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8785.90 Da        Isoelectric Point: 4.0179

>AT203941 WP_002413218.1 NZ_CP075604:418425-418652 [Enterococcus faecalis]
MAMITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Download         Length: 228 bp

>AT203941 NZ_CP100486:c2202358-2202087 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3GZA4

Antitoxin

Source ID Structure
AlphaFold DB R3JPM7

References