Detailed information of TA system TA203936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1500104..1500623
• Replicon: chromosome
• Accession: NZ_CP075595
• Organism: Pseudomonas sp. RC3H12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KHO27_RS07020
• Protein ID: WP_214501494.1
• Coordinates: 1500339..1500623 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KHO27_RS07015
• Protein ID: WP_110703854.1
• Coordinates: 1500104..1500349 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHO27_RS07005 (KHO27_07005)	1495524..1498919	-	3396	WP_214501493.1	Ig-like domain-containing protein	-
KHO27_RS07010 (KHO27_07010)	1499284..1500024	+	741	WP_110703838.1	hypothetical protein	-
KHO27_RS07015 (KHO27_07015)	1500104..1500349	+	246	WP_110703854.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KHO27_RS07020 (KHO27_07020)	1500339..1500623	+	285	WP_214501494.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KHO27_RS07025 (KHO27_07025)	1500632..1501549	-	918	WP_214501495.1	LysR family transcriptional regulator	-
KHO27_RS07030 (KHO27_07030)	1501734..1503038	+	1305	WP_110703832.1	MFS transporter	-
KHO27_RS07035 (KHO27_07035)	1503055..1504296	+	1242	WP_110703830.1	Zn-dependent hydrolase	-
KHO27_RS07040 (KHO27_07040)	1504296..1505318	+	1023	WP_214501496.1	histone deacetylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10951.80 Da
• Isoelectric Point: 10.7874

>T203936 WP_214501494.1 NZ_CP075595:1500339-1500623 [Pseudomonas sp. RC3H12]
MTYELEFLPSALKEWKKLGHTVREQARRKLKERLLSPRVGADAMRDLPDHFKIKLKASGYRVVYRVEDERVVVVVVAIGK
RERGQAYRSAADRL

Nucleotide

• Length: 285 bp

>T203936 NZ_CP100486:1058817-1059224 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8857.30 Da
• Isoelectric Point: 4.4000

>AT203936 WP_110703854.1 NZ_CP075595:1500104-1500349 [Pseudomonas sp. RC3H12]
MQNIFADVTVSVSELKKNPTAVMADAQGKPVAVLNHNRVMGYMVPAELYEAIMERLEDMELAALVKARAGEKGIPVELDD
L

Nucleotide

• Length: 246 bp

>AT203936 NZ_CP100486:1058570-1058836 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA