203935

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 677693..678293 Replicon chromosome
Accession NZ_CP075595
Organism Pseudomonas sp. RC3H12

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KHO27_RS03150 Protein ID WP_214501166.1
Coordinates 677991..678293 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KHO27_RS03145 Protein ID WP_110698019.1
Coordinates 677693..677998 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHO27_RS03130 (KHO27_03130) 675697..676089 + 393 WP_139672906.1 SMI1/KNR4 family protein -
KHO27_RS03135 (KHO27_03135) 676206..676610 + 405 WP_110698015.1 transcriptional regulator -
KHO27_RS03140 (KHO27_03140) 676702..677628 + 927 WP_110698017.1 DMT family transporter -
KHO27_RS03145 (KHO27_03145) 677693..677998 - 306 WP_110698019.1 putative addiction module antidote protein Antitoxin
KHO27_RS03150 (KHO27_03150) 677991..678293 - 303 WP_214501166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHO27_RS03155 (KHO27_03155) 678361..679524 - 1164 WP_214501167.1 MFS transporter -
KHO27_RS03160 (KHO27_03160) 679632..680525 + 894 WP_110698023.1 LysR family transcriptional regulator -
KHO27_RS26305 680650..680778 + 129 WP_256206021.1 PA1414 family protein -
KHO27_RS03165 (KHO27_03165) 680841..682811 - 1971 WP_214501168.1 bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(6-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11356.00 Da        Isoelectric Point: 10.4297

>T203935 WP_214501166.1 NZ_CP075595:c678293-677991 [Pseudomonas sp. RC3H12]
MKTIESSSFRHWLIGLRDATARARIVARVNRLKEGLAGDVSPVGHGMSELRVHYGPGYRVYFHQYGDTLIILLCGGDKSS
QQRDIKAARQILQSWRMQND

Download         Length: 303 bp

>T203935 NZ_CP100486:c942075-941698 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10897.34 Da        Isoelectric Point: 5.5900

>AT203935 WP_110698019.1 NZ_CP075595:c677998-677693 [Pseudomonas sp. RC3H12]
MTETFHEFDAAAYLTSPETIAQFMTDALETGDAAYVAKAVGVVARARGMSELAKETGLSREQLYRSFSEHGNPTLKSFLT
VMKALGIDMAARPHLSQQGVG

Download         Length: 306 bp

>AT203935 NZ_CP100486:c942533-942165 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCACGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATCCGGACCAGACCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References