Detailed information of TA system TA203932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4982560..4984241
• Replicon: chromosome
• Accession: NZ_CP075591
• Organism: Klebsiella pneumoniae strain ST17

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: KJE29_RS24620
• Protein ID: WP_004146663.1
• Coordinates: 4982560..4983477 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KJE29_RS24625
• Protein ID: WP_004177809.1
• Coordinates: 4983483..4984241 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJE29_RS24600 (4977866)	4977866..4979386	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
KJE29_RS24605 (4979383)	4979383..4980381	+	999	WP_012737175.1	ribose ABC transporter permease	-
KJE29_RS24610 (4980412)	4980412..4981353	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KJE29_RS24615 (4981428)	4981428..4982435	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
KJE29_RS24620 (4982560)	4982560..4983477	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KJE29_RS24625 (4983483)	4983483..4984241	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KJE29_RS24630 (4984327)	4984327..4985055	-	729	WP_002885152.1	response regulator transcription factor	-
KJE29_RS24635 (4985328)	4985328..4987475	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KJE29_RS24640 (4987705)	4987705..4988391	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T203932 WP_004146663.1 NZ_CP075591:c4983477-4982560 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T203932 NZ_CP100486:251759-251866 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT203932 WP_004177809.1 NZ_CP075591:c4984241-4983483 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT203932 NZ_CP100486:c251710-251647 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05