Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4822323..4822839 Replicon chromosome
Accession NZ_CP075591
Organism Klebsiella pneumoniae strain ST17

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KJE29_RS23810 Protein ID WP_002886902.1
Coordinates 4822323..4822607 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KJE29_RS23815 Protein ID WP_002886901.1
Coordinates 4822597..4822839 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJE29_RS23785 (4817739) 4817739..4818002 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KJE29_RS23790 (4818132) 4818132..4818305 + 174 WP_032410138.1 hypothetical protein -
KJE29_RS23795 (4818308) 4818308..4819051 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
KJE29_RS23800 (4819408) 4819408..4821546 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KJE29_RS23805 (4821855) 4821855..4822319 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KJE29_RS23810 (4822323) 4822323..4822607 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KJE29_RS23815 (4822597) 4822597..4822839 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KJE29_RS23820 (4822917) 4822917..4824827 - 1911 WP_009486549.1 PRD domain-containing protein -
KJE29_RS23825 (4824850) 4824850..4826004 - 1155 WP_023302389.1 lactonase family protein -
KJE29_RS23830 (4826071) 4826071..4826811 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T203931 WP_002886902.1 NZ_CP075591:c4822607-4822323 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T203931 NZ_CP100486:251276-251383 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT203931 WP_002886901.1 NZ_CP075591:c4822839-4822597 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT203931 NZ_CP100486:c251227-251164 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References