Detailed information of TA system TA203919

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 819604..820261
• Replicon: chromosome
• Accession: NZ_CP075591
• Organism: Klebsiella pneumoniae strain ST17

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: W8UCT0
• Locus tag: KJE29_RS04150
• Protein ID: WP_002916310.1
• Coordinates: 819851..820261 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KJE29_RS04145
• Protein ID: WP_002916312.1
• Coordinates: 819604..819870 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJE29_RS04120 (814760)	814760..816193	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
KJE29_RS04125 (816312)	816312..817040	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KJE29_RS04130 (817090)	817090..817401	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KJE29_RS04135 (817565)	817565..818224	+	660	WP_002916317.1	hemolysin III family protein	-
KJE29_RS04140 (818375)	818375..819358	-	984	WP_004185555.1	tRNA-modifying protein YgfZ	-
KJE29_RS04145 (819604)	819604..819870	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KJE29_RS04150 (819851)	819851..820261	+	411	WP_002916310.1	protein YgfX	Toxin
KJE29_RS04155 (820268)	820268..820789	-	522	WP_004144730.1	flavodoxin FldB	-
KJE29_RS04160 (820890)	820890..821786	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KJE29_RS04165 (821809)	821809..822522	+	714	WP_004185548.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KJE29_RS04170 (822528)	822528..824261	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16049.85 Da
• Isoelectric Point: 11.4778

>T203919 WP_002916310.1 NZ_CP075591:819851-820261 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T203919 NZ_CP100479:36960-37430 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT203919 WP_002916312.1 NZ_CP075591:819604-819870 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT203919 NZ_CP100479:36520-36963 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATAAATGAAGGTCTGGACGGGAAGGTGGCGAACCGGATAACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GSW7

Antitoxin

• AlphaFold DB: A0A0H3GY41