Detailed information of TA system TA203914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 5515039..5515544
• Replicon: chromosome
• Accession: NZ_CP075567
• Organism: Pseudomonas fitomaticsae strain FIT81

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q3K782
• Locus tag: KJY40_RS24885
• Protein ID: WP_011335833.1
• Coordinates: 5515290..5515544 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KJY40_RS24880
• Protein ID: WP_230733374.1
• Coordinates: 5515039..5515293 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJY40_RS24850 (KJY40_24800)	5510665..5510994	+	330	WP_230733364.1	hypothetical protein	-
KJY40_RS24855 (KJY40_24805)	5510999..5511367	-	369	WP_095191588.1	PH domain-containing protein	-
KJY40_RS24860 (KJY40_24810)	5511404..5511544	-	141	WP_230733366.1	hypothetical protein	-
KJY40_RS24865 (KJY40_24815)	5511667..5512017	+	351	WP_230733368.1	hypothetical protein	-
KJY40_RS24870 (KJY40_24820)	5512151..5512849	+	699	WP_230733370.1	hypothetical protein	-
KJY40_RS24875 (KJY40_24825)	5512920..5514839	+	1920	WP_230733373.1	alkaline phosphatase D family protein	-
KJY40_RS24880 (KJY40_24830)	5515039..5515293	+	255	WP_230733374.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KJY40_RS24885 (KJY40_24835)	5515290..5515544	+	255	WP_011335833.1	Txe/YoeB family addiction module toxin	Toxin
KJY40_RS24890 (KJY40_24840)	5515553..5516725	-	1173	WP_230733376.1	aspartate aminotransferase family protein	-
KJY40_RS24895 (KJY40_24845)	5516826..5517731	+	906	WP_230733379.1	LysR family transcriptional regulator	-
KJY40_RS24900 (KJY40_24850)	5517777..5518181	+	405	WP_230733380.1	GNAT family N-acetyltransferase	-
KJY40_RS24905 (KJY40_24855)	5518367..5519848	+	1482	WP_230733382.1	MBOAT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9950.59 Da
• Isoelectric Point: 9.6300

>T203914 WP_011335833.1 NZ_CP075567:5515290-5515544 [Pseudomonas fitomaticsae]
MKIQFTPTGWEDYLWFQQNDKAGLKRINLLIKAIQRQPFEGLGKPEPLKHNMSGFWSRRITAEHRLVYAIVDGEICVITC
RFHY

Nucleotide

• Length: 255 bp

>T203914 NZ_CP100478:3933018-3933236 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9427.83 Da
• Isoelectric Point: 5.1314

>AT203914 WP_230733374.1 NZ_CP075567:5515039-5515293 [Pseudomonas fitomaticsae]
MDTINYTTARAHLAETMDRVNEDCAPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSSANAERLIKSIGEMRAGKAKVRQ
LIEE

Nucleotide

• Length: 255 bp

>AT203914 NZ_CP100478:3932617-3932991 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: Q3K782