Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1744577..1745200 | Replicon | chromosome |
| Accession | NZ_CP075567 | ||
| Organism | Pseudomonas fitomaticsae strain FIT81 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | KJY40_RS07840 | Protein ID | WP_007957952.1 |
| Coordinates | 1745021..1745200 (-) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | J2PMX3 |
| Locus tag | KJY40_RS07835 | Protein ID | WP_007957951.1 |
| Coordinates | 1744577..1744984 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KJY40_RS07805 (KJY40_07795) | 1739952..1741037 | + | 1086 | WP_230735967.1 | type I restriction enzyme HsdR N-terminal domain-containing protein | - |
| KJY40_RS07810 (KJY40_07800) | 1741198..1741968 | + | 771 | WP_230735969.1 | trans-aconitate 2-methyltransferase | - |
| KJY40_RS07815 (KJY40_07805) | 1741996..1742724 | - | 729 | WP_230735971.1 | class I SAM-dependent methyltransferase | - |
| KJY40_RS07820 (KJY40_07810) | 1743248..1743616 | + | 369 | WP_230735972.1 | DUF6124 family protein | - |
| KJY40_RS07825 (KJY40_07815) | 1743697..1744056 | - | 360 | WP_085683210.1 | transcriptional regulator | - |
| KJY40_RS07830 (KJY40_07820) | 1744056..1744358 | - | 303 | WP_085683209.1 | type II toxin-antitoxin system HigB family toxin | - |
| KJY40_RS07835 (KJY40_07825) | 1744577..1744984 | - | 408 | WP_007957951.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KJY40_RS07840 (KJY40_07830) | 1745021..1745200 | - | 180 | WP_007957952.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KJY40_RS07845 (KJY40_07835) | 1745423..1745833 | - | 411 | WP_039772722.1 | PaaI family thioesterase | - |
| KJY40_RS07855 (KJY40_07845) | 1746362..1747246 | - | 885 | WP_230735974.1 | alpha/beta hydrolase | - |
| KJY40_RS07860 (KJY40_07850) | 1747563..1748255 | - | 693 | WP_230735976.1 | pseudouridine synthase | - |
| KJY40_RS07865 (KJY40_07855) | 1748289..1748507 | - | 219 | WP_007957955.1 | cysteine-rich CWC family protein | - |
| KJY40_RS07870 (KJY40_07860) | 1748513..1750000 | - | 1488 | WP_230735978.1 | sensor domain-containing diguanylate cyclase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1734376..1745833 | 11457 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6660.91 Da Isoelectric Point: 11.4113
>T203911 WP_007957952.1 NZ_CP075567:c1745200-1745021 [Pseudomonas fitomaticsae]
VNSRFLIGQLVADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL
VNSRFLIGQLVADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL
Download Length: 180 bp
>T203911 NZ_CP100478:812317-812727 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14627.66 Da Isoelectric Point: 4.7269
>AT203911 WP_007957951.1 NZ_CP075567:c1744984-1744577 [Pseudomonas fitomaticsae]
MLYPIAISVGDEGHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQR
MLYPIAISVGDEGHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQR
Download Length: 408 bp
>AT203911 NZ_CP100478:812070-812336 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|