Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5943391..5944034 Replicon chromosome
Accession NZ_CP075566
Organism Pseudomonas fluorescens strain G20-18

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KJF94_RS27650 Protein ID WP_214380165.1
Coordinates 5943391..5943573 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KJF94_RS27655 Protein ID WP_214380166.1
Coordinates 5943570..5944034 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJF94_RS27630 (KJF94_27630) 5939111..5941066 + 1956 WP_214384965.1 choline transporter BetT -
KJF94_RS27635 (KJF94_27635) 5941069..5941329 - 261 WP_214380162.1 hypothetical protein -
KJF94_RS27640 (KJF94_27640) 5941500..5942240 - 741 WP_214380163.1 SDR family oxidoreductase -
KJF94_RS27645 (KJF94_27645) 5942370..5943260 + 891 WP_214380164.1 LysR family transcriptional regulator -
KJF94_RS27650 (KJF94_27650) 5943391..5943573 + 183 WP_214380165.1 type II toxin-antitoxin system HicA family toxin Toxin
KJF94_RS27655 (KJF94_27655) 5943570..5944034 + 465 WP_214380166.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KJF94_RS27660 (KJF94_27660) 5944195..5945232 + 1038 WP_214380167.1 L-glyceraldehyde 3-phosphate reductase -
KJF94_RS27665 (KJF94_27665) 5945397..5946239 - 843 WP_214380168.1 taurine dioxygenase -
KJF94_RS27670 (KJF94_27670) 5946295..5947128 - 834 WP_214380169.1 taurine ABC transporter permease TauC -
KJF94_RS27675 (KJF94_27675) 5947125..5947919 - 795 WP_214380170.1 taurine ABC transporter ATP-binding subunit -
KJF94_RS27680 (KJF94_27680) 5947936..5948913 - 978 WP_214380171.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(24-148)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6965.04 Da        Isoelectric Point: 10.1780

>T203908 WP_214380165.1 NZ_CP075566:5943391-5943573 [Pseudomonas fluorescens]
MRSREMIRMIEEDGWYLVAVKDSHHQYKHSYKAGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

>T203908 NZ_CP100476:c4978196-4977780 [Mesorhizobium sp. C120A]
ATGATCCTCCTCGATACCAATGTCGTTTCGGAGGCCATGAAGCCCGAACCGCATCAAGCTGTGTTGGCCTGGCTTGATGA
CCAGGCCGAGGAAACGCTTTACCTCTCCAGTGTGACGCTCGCCGAAGTGCTGTTCGGCATCGAGGCCATGCCGGCGGGTC
GTCGCAAGGCTGCGCTCGCTGAAACCTTCGCCGGTGTGTGCGCCGTGTTTGAGCGCCGCATCCTGCCTTTCGATACCGAG
GCGGCCCGGCACTATGCCCGACTTGCAGTGAAGGCGAGGGCAGCCGGCAAGGGGTTTCCTGTGCCCGACGGCTACATCGC
GGCAATCGCCTCCGCAAACGGCTTTCATCTCGCCTCGCGTGACACGGCGCCATTCCATGCGGCCGGCGTGCCTGTCATCG
ATCCTTGGCAGCCGTAA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16785.68 Da        Isoelectric Point: 4.1507

>AT203908 WP_214380166.1 NZ_CP075566:5943570-5944034 [Pseudomonas fluorescens]
MTPDIGNESLEGATAQEGLTEMKFPVVLHKDADSEYGVIIPDVPGCFSAGATVAQAFENVKEALSLHYEGLVADGDPLPQ
VREIDAHIDNPDYAGGVWGVVDFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSE

Download         Length: 465 bp

>AT203908 NZ_CP100476:c4978447-4978193 [Mesorhizobium sp. C120A]
ATGCCTGCAGTGACCGTCCGAAATCTTCCGGAAGCGACCCACCGAGCTCTGCGTGTACGGGCGGCCTTGCACGGTCGCAG
CACCGAGGCCGAGATACGCGACATTCTAGAAAACGCGGTGCGGCCGGACGGCCGTGTGAAACTCGGCTCCGTTCTGGCAG
ACATTGCCCGACGCGCCGGGCTGACCAATGAAGACGTGGAGGTCCTGGAGCAGGCTCGCGACAAGGCGCCGGCCGAACCG
CTGGGGTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References