Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1060779..1061395 Replicon chromosome
Accession NZ_CP075566
Organism Pseudomonas fluorescens strain G20-18

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KJF94_RS04930 Protein ID WP_214381589.1
Coordinates 1060779..1060991 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KJF94_RS04935 Protein ID WP_214381591.1
Coordinates 1060991..1061395 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJF94_RS04905 (KJF94_04905) 1056362..1057081 + 720 WP_214381579.1 phosphonate C-P lyase system protein PhnL -
KJF94_RS04910 (KJF94_04910) 1057071..1058216 + 1146 WP_214381581.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
KJF94_RS04915 (KJF94_04915) 1058216..1058782 + 567 WP_214381583.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
KJF94_RS04920 (KJF94_04920) 1058773..1059522 + 750 WP_214381585.1 phosphonate metabolism protein PhnP -
KJF94_RS04925 (KJF94_04925) 1059644..1060531 - 888 WP_214381587.1 LysR family transcriptional regulator -
KJF94_RS04930 (KJF94_04930) 1060779..1060991 + 213 WP_214381589.1 type II toxin-antitoxin system HicA family toxin Toxin
KJF94_RS04935 (KJF94_04935) 1060991..1061395 + 405 WP_214381591.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KJF94_RS04940 (KJF94_04940) 1061490..1062695 - 1206 WP_214381593.1 MFS transporter -
KJF94_RS04945 (KJF94_04945) 1062932..1063549 + 618 WP_214381595.1 hypothetical protein -
KJF94_RS04950 (KJF94_04950) 1063770..1064768 - 999 WP_214381597.1 sulfate ABC transporter substrate-binding protein -
KJF94_RS04955 (KJF94_04955) 1064862..1065686 - 825 WP_214381599.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7936.14 Da        Isoelectric Point: 9.9104

>T203907 WP_214381589.1 NZ_CP075566:1060779-1060991 [Pseudomonas fluorescens]
VQSRLLIKELEEAGWTLDRITGSHHLFTHRYNPYTIPVPHPKKDLPIGTVKSIRRRAGLYCPPASYAGDP

Download         Length: 213 bp

>T203907 NZ_CP100476:4043937-4044137 [Mesorhizobium sp. C120A]
ATGCCGCCTCGGCTTACAGTCCGCGAAGTCATTCGCCTGCTGGAGACCGACGGTTGGTATCTGGTTGCAACCAAGGGCAG
CCATCGCCAATATAAGCACAAAACCAAAGCCGGCCGCGTCACCGTGGCCGGCAAACCGTCTGAAGAGGTTGCGCCAGGAA
CACTGAACAGCATCCTCAAGCAGTCCGGTTTGAAGGAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14745.76 Da        Isoelectric Point: 4.3841

>AT203907 WP_214381591.1 NZ_CP075566:1060991-1061395 [Pseudomonas fluorescens]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAIEIAHIMLQEIAADGEAIPMPSSAAVHRGNPDFADMGWGM
LELDIAPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp

>AT203907 NZ_CP100476:4044142-4044348 [Mesorhizobium sp. C120A]
ATGCGTTACGCGGTGGTGATTGAAAAAGCAGGCAACAATTTCTCTGCCTATGTGCCGGACCTACCCGGCTGCATCGCAAC
TGGTGCTACCGTGCCAGAAGTAGAAATCGAAATTCGCGACGCTATACGCTTTCACATCGAGGGCTTGCGTGCCGATGGGC
TGGAGGTGCCCAAAGGAATCAGTCTCGCGGAATACGTAGAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References