Detailed information of TA system TA203904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1899482..1901046
• Replicon: chromosome
• Accession: NZ_CP075564
• Organism: Aeromonas media strain TR3_1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A3G9I6T8
• Locus tag: KI797_RS08805
• Protein ID: WP_064338156.1
• Coordinates: 1899482..1900792 (-)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KI797_RS08810
• Protein ID: WP_005329233.1
• Coordinates: 1900792..1901046 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI797_RS08780 (KI797_08775)	1895099..1895554	+	456	WP_161507131.1	YbjN domain-containing protein	-
KI797_RS08795 (KI797_08790)	1896196..1898370	-	2175	WP_226172610.1	catalase/peroxidase HPI	-
KI797_RS08805 (KI797_08800)	1899482..1900792	-	1311	WP_064338156.1	type II toxin-antitoxin system HipA family toxin	Toxin
KI797_RS08810 (KI797_08805)	1900792..1901046	-	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
KI797_RS08815 (KI797_08810)	1901609..1902589	-	981	WP_026141181.1	IS5-like element IS5 family transposase	-
KI797_RS08820 (KI797_08815)	1902630..1903361	-	732	WP_226172613.1	J domain-containing protein	-
KI797_RS08825 (KI797_08820)	1903543..1903750	-	208	Protein_1679	IS21-like element ISAs29 family helper ATPase IstB	-
KI797_RS08830 (KI797_08825)	1903999..1905255	+	1257	WP_021140988.1	hypothetical protein	-
KI797_RS08835 (KI797_08830)	1905252..1905860	+	609	WP_005330555.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1901609..1902589	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49124.32 Da
• Isoelectric Point: 7.1717

>T203904 WP_064338156.1 NZ_CP075564:c1900792-1899482 [Aeromonas media]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSRAQRLKR

Nucleotide

• Length: 1311 bp

>T203904 NZ_CP100476:2365193-2366062 [Mesorhizobium sp. C120A]
ATGGCTAGAGGCACTACAAATCAGGCTGCCTCGATCAAGCAGCGATTACTGAACCTCGCGCGCAAGGAAGGCCGGATCTA
TGAGGTCGTGCTGGTGCGCTACGCGCTGGAACGGATGCTCTACCGCCTGTCTGTCTCGGACCAGCGCGATCGTTTCATTC
TGAAGGGAGGGATGCTCGTTACCCTATGGATCGACGGTGGCAATCGCGAGACGCGAGACGCTGACTTTCTTGGGCACGGC
GATGCCAACCCGGAAAAGCTCAAAGCTACATTTGCCGAAATCATGGCAATCGCTACCGACGATGGGCTTGTATTCGATAC
CCAAGGCCTGACTGCAACTACGATCCGCGAAGAGATGGAATATGGCGGGGTGCGCCTACGCACGACGGCCTTTTTGGAGC
GGTCCAGGATCCCAGTTACGATCGACATAGGGTTTGGCGACGCTCTGGCGGCAGCGGCGCAACCGCTCGCCTATCCATCG
TTGCTTGGCATGGAGACGCCGCAGATACGGACCTATCCCCCGGCAACAGTTATCGCTGAGAAATTTCAGGCCATGGTCGC
GCTGGGCATCGCCAACGGTCGCATGAAAGATTACTACGATCTGTGGGCGATCCCCAAGGCAGTCCCTCTCGCAGATACGG
ATCTGGATGCTGCTATCCGAGCGACTTTCGAGCGGCGACATACTGACATTCCTGACGGTAGGCCACCTGGTCTTTCAACG
ACATTGCTGGACGATGCGACCAAGCAGCGCCAATGGCATGCCTACGCACAATCAATCGACCACGACGGCCTGTCGCTGGT
GGAGGTTGTGGATGCCGTCTGGGCGCTGGTGGGACCATCGTGCGCGCGCATCAGATCGTCTGACAATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT203904 WP_005329233.1 NZ_CP075564:c1901046-1900792 [Aeromonas media]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT203904 NZ_CP100476:2364580-2365200 [Mesorhizobium sp. C120A]
ATGGACCGGACTCAAACAACCCAACGCCAACAACTGGCTGCCCTCCTGGACACCCAGCCAATCATGCGCGCATATGAACT
CCGCAAGGCCGGGATTGCGCCCGAGACGATCTCGCGCGCTGTCCACAATGGCCAACTCATCCGCATCTCCCGCGGCCTCT
ATCAACGCGCCGACAGTGAAGTCGAAACCGAGCAGGCGCTCGCAGAAGCTGCAAAGAGGGTCCCCAAAGGCGTCATTGCC
ATGGTTTCGGCGCTCGCCTTTCACGGGCTGACCGACCAGATGCCTCGCAAGATATGGGTCGCAATCAGCGCGAGGGACTG
GGCACCGGTTCCTTCATATCCGCCGATCCGCATCGTCGAACTTCGTGACAGGTACATGGACCAAGGAATCGAGCATCATC
GAATTTCGGGAGTCGACGTTCCGATCTTCTCGGTCCCGAAGACGCTCGCCGATATCTTCCGCAACCGCAAGCTGGTCGAC
CGCTCGGTTGCAGTGGAGGGGCTGCGAGCTGCCCTCGACCAGCGTAAGGCCACACCTGGTACTATCGCGGAGGCGGCAAT
CGCAGGCGACTCCTGGAAGATCATGCGCCCTTATCTCGAGGCTCTGACCTCGAATGGCTAG

Structures

Toxin

• AlphaFold DB: A0A3G9I6T8