Detailed information of TA system TA203903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2385323..2385800
• Replicon: chromosome
• Accession: NZ_CP075563
• Organism: Staphylococcus aureus strain Sta2021027

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KJP35_RS11770
• Protein ID: WP_000052076.1
• Coordinates: 2385612..2385800 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KJP35_RS11765
• Protein ID: WP_001059690.1
• Coordinates: 2385323..2385583 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJP35_RS11730 (2380716)	2380716..2381432	-	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-
KJP35_RS11735 (2381580)	2381580..2382002	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
KJP35_RS11740 (2382401)	2382401..2382895	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KJP35_RS11745 (2383050)	2383050..2383667	+	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
KJP35_RS11750 (2383740)	2383740..2384321	-	582	WP_001140697.1	histidine phosphatase family protein	-
KJP35_RS11755 (2384546)	2384546..2384782	+	237	WP_000368687.1	hypothetical protein	-
KJP35_RS11760 (2384779)	2384779..2384982	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KJP35_RS11765 (2385323)	2385323..2385583	+	261	WP_001059690.1	hypothetical protein	Antitoxin
KJP35_RS11770 (2385612)	2385612..2385800	+	189	WP_000052076.1	hypothetical protein	Toxin
KJP35_RS11775 (2385988)	2385988..2386557	+	570	WP_045178121.1	lipoprotein N-acylation protein LnsA	-
KJP35_RS11780 (2386645)	2386645..2386929	+	285	WP_001004401.1	hypothetical protein	-
KJP35_RS11785 (2386991)	2386991..2387209	+	219	WP_000005886.1	hypothetical protein	-
KJP35_RS11790 (2387705)	2387705..2387905	-	201	WP_001059082.1	cold-shock protein	-
KJP35_RS11795 (2388262)	2388262..2388948	-	687	WP_001566557.1	thermonuclease family protein	-
KJP35_RS11800 (2389289)	2389289..2389759	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T203903 WP_000052076.1 NZ_CP075563:2385612-2385800 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T203903 NZ_CP100476:2132791-2133177 [Mesorhizobium sp. C120A]
GTGACCTACCTGCTCGACACCAATGCCGTCATAGCGATCATCGCGGGCGACGAGGGTCTGCTGGCATTGCTCAAACGGCA
TGCACCACAAGACTTTGCTCTCTCGGCGGTCGTTTTGCATGAGCTGTACTACGGCGCTGAAAAGAGCCAGCGAAAGGTCC
AAAATCTGGCGCGCATCGAAGCTTTGCAGTTCCCGGTACTTGAATTCGACCGAGACGACGCGAGACATGCCGGCGAGATT
CGTGCTGGGCTTGCGGCACTGGGAACCCCGATTGGTCCCTACGATGCGCTGATTGGCGGGCAGGCACGTGCTCGGGACCT
CACGCTGATAACCCGCAATATCCGGGAATTCGAGCGGATCAAAGATCTCACTATCGAAACGTGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT203903 WP_001059690.1 NZ_CP075563:2385323-2385583 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT203903 NZ_CP100476:2132549-2132794 [Mesorhizobium sp. C120A]
ATGGACAAGGCAAAGGTGTTCTGGTCAGGCCGGTCACAAGCTGTGCGCTTGCCTAAGGAGTTTCGGTTCGAGGCAGATGA
GGTTTCGATCCGTCGTCATGGGCAAACTGTCATCTTGGAGCCGCTTGCGCAGGATTGGGCATGGCTCGACCAGGTCATCG
GACCGGTTGACGACGATTTCGTCCAGGGAGCGCTGGAGCGTCAGGATGGTCAGGATCGACCTGCTTTGGATGACCTCTTT
AAGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56