Detailed information of TA system TA203900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1337397..1338173
• Replicon: chromosome
• Accession: NZ_CP075563
• Organism: Staphylococcus aureus strain Sta2021027

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KJP35_RS06755
• Protein ID: WP_000031108.1
• Coordinates: 1338021..1338173 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KJP35_RS06750
• Protein ID: WP_001251224.1
• Coordinates: 1337397..1337996 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJP35_RS06730 (1333313)	1333313..1334770	+	1458	WP_000649907.1	ABC transporter permease subunit	-
KJP35_RS06735 (1334763)	1334763..1335485	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KJP35_RS06740 (1335636)	1335636..1336763	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KJP35_RS06745 (1336768)	1336768..1337238	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KJP35_RS06750 (1337397)	1337397..1337996	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KJP35_RS06755 (1338021)	1338021..1338173	+	153	WP_000031108.1	SAS053 family protein	Toxin
KJP35_RS06760 (1338776)	1338776..1339171	+	396	WP_000901023.1	hypothetical protein	-
KJP35_RS06765 (1339367)	1339367..1340752	+	1386	WP_000116229.1	class II fumarate hydratase	-
KJP35_RS06770 (1341215)	1341215..1342036	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T203900 WP_000031108.1 NZ_CP075563:1338021-1338173 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T203900 NZ_CP100476:c507671-507249 [Mesorhizobium sp. C120A]
GTGAGACTGCTGCTCGACACGAATGTCCTGTCCGAGGTGACGAGGCCAGCGCCTGTCGCACGTGTCCTGGGCTGGCTGGA
CGAGCTTGATGAGGACCGCTCCTTCATCAGCGTAGTGTCGATCGCCGAGATCCGGCGCGGCGTCTCTCTGATGGATGAGG
GCCGCAAACGCGAGGCGCTGGCCGAATGGCTCGCCCGGGACCTGCCCCAGCGCTTCGAACAGCGGGTTTTGCCGGTGGAC
GATGCGGTTGCCTTGGCCTGGGGCGACCTGATGGGTTTTGGCAAGCGCCGCGGTCGTGGTCTATCGTCGATGGACGGGCT
GATCGCAGCCACTGCGATTGCGCACGAGCTCACCTTGGCAACGCGCAATACGAAACATTTCGAAGGCTTTGGGCTTGAAC
TCTTCGATCCCTGGACCGCATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT203900 WP_001251224.1 NZ_CP075563:1337397-1337996 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT203900 NZ_CP100476:c507931-507668 [Mesorhizobium sp. C120A]
ATGCTAACGTCATCCAAAGGCACCAACTGGACGGTTGCCGGGGCAAAAGCCCGGCTCTCCGAGGTCATCGAGCGCGCGCA
GTCCTCGCCGCAGACGATCACCAAGAACGGCAAACCAAGCGTGGTTGTCGTCTCGGCCGAGGAATGGCAGCGCAAGATCG
CACGCAAGGGTACGCTTGCCGAGTTCCTGCTGGACTCGCCGCTGCGCGGCGCCGATCTCGACCTTGAACGTCAGCGCGAC
GAACCGCGTGACCTGCCGCGGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4