203894

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1120257..1120771 Replicon chromosome
Accession NZ_CP075563
Organism Staphylococcus aureus strain Sta2021027

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KJP35_RS05415 Protein ID WP_000581792.1
Coordinates 1120562..1120771 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KJP35_RS05410 Protein ID WP_000138932.1
Coordinates 1120257..1120550 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP35_RS05390 (1115867) 1115867..1116508 + 642 WP_000483164.1 thiamine phosphate synthase -
KJP35_RS05395 (1116594) 1116594..1117466 + 873 WP_000725802.1 membrane protein insertase YidC -
KJP35_RS05400 (1117932) 1117932..1118579 - 648 WP_001187630.1 HD domain-containing protein -
KJP35_RS05405 (1118607) 1118607..1120091 - 1485 WP_000571549.1 cardiolipin synthase -
KJP35_RS05410 (1120257) 1120257..1120550 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KJP35_RS05415 (1120562) 1120562..1120771 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KJP35_RS05420 (1120899) 1120899..1121036 + 138 WP_000828354.1 Lmo0850 family protein -
KJP35_RS05425 (1121300) 1121300..1122502 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KJP35_RS05430 (1122820) 1122820..1123890 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KJP35_RS05435 (1123905) 1123905..1125263 + 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T203894 WP_000581792.1 NZ_CP075563:1120562-1120771 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T203894 NZ_CP100475:3562636-3563034 [Mesorhizobium sp. C372A]
ATGCGGTTCATGCTGGACACGAACATCATCAGCGACATGATCCGAAATCCGGCCGGCAAAGCCGCCAGTACGGCGGTTCG
CGCGGGAGACGGTGCCCTGTGCACCAGCATCGTTGTCGCCTCGGAGCTGCGTTATGGCTGCGCCCGCAAGGGATCGGCCA
AGCTGCTCGCCAAGGTCGAGCAATTGCTCGCCGAGTTACCTGTGCTGCCGCTCGATGTGCCGATGGATAACGAATACGGA
GCACTTCGTGCCGAGCTGGAGGCCAGAGGCCAGCCAATCGGCCACAATGATCTTTTCATTGCTGCCCATGCCTGTGTGTT
GGGGACGACACTGGTGACGGCCAACACCGCTGAGTTCCGTCGGATCAAGGGCCTGACGGTCGAGAACTGGCTGGAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT203894 WP_000138932.1 NZ_CP075563:1120257-1120550 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT203894 NZ_CP100475:3562364-3562636 [Mesorhizobium sp. C372A]
ATGCCGCAGCACCGTCACTCGATACCACCGCCCAGGGAGGCGAAGTTGTTTCGCAACAACCGCAGTCAGGCGGTTCGCAT
CCCTGTCGAATTCGAGCTGCCTGGGGAGAAGGTCCTGATCAGCCGCGATGGCGACCGGCTGATCATCGAGCCGGTCCGTA
AACCGGGACTTGTCGCGCTGCTTGCCCAATGGGCGAAAGAGCCGCCGCTTGGTCCTGAAGACGACTTTCCCGAGATCCAT
GATGCGCCCGTGGGGCCCGAGGACATCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References