Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1657736..1658250 Replicon chromosome
Accession NZ_CP075562
Organism Staphylococcus aureus strain Sta2021010

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KI818_RS08465 Protein ID WP_000581793.1
Coordinates 1657736..1657945 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KI818_RS08470 Protein ID WP_000138932.1
Coordinates 1657957..1658250 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI818_RS08445 (1653245) 1653245..1654603 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KI818_RS08450 (1654618) 1654618..1655688 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KI818_RS08455 (1656006) 1656006..1657208 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KI818_RS08460 (1657471) 1657471..1657608 - 138 WP_000828354.1 Lmo0850 family protein -
KI818_RS08465 (1657736) 1657736..1657945 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KI818_RS08470 (1657957) 1657957..1658250 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KI818_RS08475 (1658416) 1658416..1659900 + 1485 WP_000571552.1 cardiolipin synthase -
KI818_RS08480 (1659928) 1659928..1660575 + 648 WP_001187627.1 HD domain-containing protein -
KI818_RS08485 (1661287) 1661287..1662159 - 873 WP_000725802.1 membrane protein insertase YidC -
KI818_RS08490 (1662245) 1662245..1662886 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T203880 WP_000581793.1 NZ_CP075562:c1657945-1657736 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T203880 NZ_CP075562:c1657945-1657736 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT203880 WP_000138932.1 NZ_CP075562:c1658250-1657957 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT203880 NZ_CP075562:c1658250-1657957 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References