Detailed information of TA system TA203879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1637996..1638525
• Replicon: chromosome
• Accession: NZ_CP075562
• Organism: Staphylococcus aureus strain Sta2021010

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KI818_RS08375
• Protein ID: WP_000621175.1
• Coordinates: 1637996..1638358 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: KI818_RS08380
• Protein ID: WP_000948331.1
• Coordinates: 1638355..1638525 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI818_RS08355 (1634975)	1634975..1635745	-	771	WP_001041102.1	RNA polymerase sigma factor SigB	-
KI818_RS08360 (1635720)	1635720..1636199	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
KI818_RS08365 (1636201)	1636201..1636527	-	327	WP_001052491.1	anti-sigma factor antagonist	-
KI818_RS08370 (1636646)	1636646..1637647	-	1002	WP_061839378.1	PP2C family protein-serine/threonine phosphatase	-
KI818_RS08375 (1637996)	1637996..1638358	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KI818_RS08380 (1638355)	1638355..1638525	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
KI818_RS08385 (1638610)	1638610..1639758	-	1149	WP_001281151.1	alanine racemase	-
KI818_RS08390 (1639824)	1639824..1640183	-	360	WP_000581200.1	holo-ACP synthase	-
KI818_RS08395 (1640187)	1640187..1640678	-	492	WP_001205910.1	PH domain-containing protein	-
KI818_RS08400 (1640665)	1640665..1642248	-	1584	WP_001294626.1	PH domain-containing protein	-
KI818_RS08405 (1642241)	1642241..1642720	-	480	WP_001287090.1	hypothetical protein	-
KI818_RS08410 (1642929)	1642929..1643489	-	561	WP_001092416.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T203879 WP_000621175.1 NZ_CP075562:c1638358-1637996 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T203879 NZ_CP100432:1605152-1605334 [Streptococcus suis T15]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT203879 WP_000948331.1 NZ_CP075562:c1638525-1638355 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT203879 NZ_CP100432:1605374-1605826 [Streptococcus suis T15]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTAACGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1