Detailed information of TA system TA203875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1440196..1440972
• Replicon: chromosome
• Accession: NZ_CP075562
• Organism: Staphylococcus aureus strain Sta2021010

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KI818_RS07145
• Protein ID: WP_000031108.1
• Coordinates: 1440196..1440348 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KI818_RS07150
• Protein ID: WP_001251224.1
• Coordinates: 1440373..1440972 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI818_RS07130 (1436344)	1436344..1437165	+	822	WP_000669373.1	RluA family pseudouridine synthase	-
KI818_RS07135 (1437618)	1437618..1439003	-	1386	WP_000116230.1	class II fumarate hydratase	-
KI818_RS07140 (1439199)	1439199..1439594	-	396	WP_000901023.1	hypothetical protein	-
KI818_RS07145 (1440196)	1440196..1440348	-	153	WP_000031108.1	SAS053 family protein	Toxin
KI818_RS07150 (1440373)	1440373..1440972	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KI818_RS07155 (1441131)	1441131..1441601	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KI818_RS07160 (1441606)	1441606..1442733	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
KI818_RS07165 (1442884)	1442884..1443606	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KI818_RS07170 (1443599)	1443599..1445056	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / lukD / hlgA	1381026..1443612	62586

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T203875 WP_000031108.1 NZ_CP075562:c1440348-1440196 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T203875 NZ_CP100431:1904831-1905676 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTCATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAGAGTACCTACTCAAATCACTATATCTTCAAAGGGGGGTTTCTGC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATGACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGAGAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAAAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTTATAACAGTACTCATTTCTATAAATTCTGATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT203875 WP_001251224.1 NZ_CP075562:c1440972-1440373 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT203875 NZ_CP100431:1904244-1904834 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGACTGTAAAGCCTTAAA
GATTCCTACAATATATTTGACAAGACTAGAAAAAGAAGGGATTATTTACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTGTTTTCTCTTATATCTCAGCGCTTTACCTG
CAGCAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAAGTAA
GAGTGTATGATTTTGAACGCATTATCTGTGATTTTGTCATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4